| http://purl.uniprot.org/citations/16357325 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16357325 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16357325 | http://www.w3.org/2000/01/rdf-schema#comment | "Mammalian Glyco_18-domain-containing proteins include catalytically active chitinases and chitinase-like proteins with cytokine activity involved in host defense and Th2-type inflammatory reactions. Here, we describe a novel human Glyco_18-domain-containing protein, SI-CLP, as an interacting partner of the endocytic/sorting receptor stabilin-1. Similarly to the chitinase-like cytokines YKL-39, YKL-40, and YM1/2, SI-CLP lacks a chitin-binding domain and catalytic amino acids. Using a novel mAb 1C11, we demonstrated that SI-CLP is sorted into late endosomes and secretory lysosomes in human alternatively activated macrophages. The direct interaction of SI-CLP with stabilin-1, their colocalization in the trans-Golgi network, and the reduced sorting of SI-CLP into lysosomes in macrophages treated with stabilin-1 siRNA suggest that stabilin-1 is involved in intracellular sorting of SI-CLP. Expression of SI-CLP in macrophages was strongly up-regulated by the Th2 cytokine IL-4 and by dexamethasone. This effect was suppressed by IFNgamma but not affected by IL-10. In contrast, expression of YKL-40 was induced by IFNgamma and suppressed by dexamethasone. Macrophages treated with IL-4 secreted SI-CLP, while costimulation with dexamethasone blocked secretion and resulted in intracellular accumulation of SI-CLP. The 1C11 mAb detected SI-CLP in human bronchoalveolar lavage and peripheral-blood leukocytes (PBLs), and can be used to analyze the role of SI-CLP in human disorders."xsd:string |
| http://purl.uniprot.org/citations/16357325 | http://purl.org/dc/terms/identifier | "doi:10.1182/blood-2005-07-2843"xsd:string |
| http://purl.uniprot.org/citations/16357325 | http://purl.org/dc/terms/identifier | "doi:10.1182/blood-2005-07-2843"xsd:string |
| http://purl.uniprot.org/citations/16357325 | http://purl.uniprot.org/core/author | "Kremmer E."xsd:string |
| http://purl.uniprot.org/citations/16357325 | http://purl.uniprot.org/core/author | "Kremmer E."xsd:string |
| http://purl.uniprot.org/citations/16357325 | http://purl.uniprot.org/core/author | "Schledzewski K."xsd:string |
| http://purl.uniprot.org/citations/16357325 | http://purl.uniprot.org/core/author | "Schledzewski K."xsd:string |
| http://purl.uniprot.org/citations/16357325 | http://purl.uniprot.org/core/author | "Mamidi S."xsd:string |
| http://purl.uniprot.org/citations/16357325 | http://purl.uniprot.org/core/author | "Mamidi S."xsd:string |
| http://purl.uniprot.org/citations/16357325 | http://purl.uniprot.org/core/author | "Kzhyshkowska J."xsd:string |
| http://purl.uniprot.org/citations/16357325 | http://purl.uniprot.org/core/author | "Kzhyshkowska J."xsd:string |
| http://purl.uniprot.org/citations/16357325 | http://purl.uniprot.org/core/author | "Krusell L."xsd:string |
| http://purl.uniprot.org/citations/16357325 | http://purl.uniprot.org/core/author | "Krusell L."xsd:string |
| http://purl.uniprot.org/citations/16357325 | http://purl.uniprot.org/core/author | "Goerdt S."xsd:string |
| http://purl.uniprot.org/citations/16357325 | http://purl.uniprot.org/core/author | "Goerdt S."xsd:string |
| http://purl.uniprot.org/citations/16357325 | http://purl.uniprot.org/core/author | "Gratchev A."xsd:string |
| http://purl.uniprot.org/citations/16357325 | http://purl.uniprot.org/core/author | "Gratchev A."xsd:string |
| http://purl.uniprot.org/citations/16357325 | http://purl.uniprot.org/core/author | "Haus G."xsd:string |
| http://purl.uniprot.org/citations/16357325 | http://purl.uniprot.org/core/author | "Haus G."xsd:string |
| http://purl.uniprot.org/citations/16357325 | http://purl.uniprot.org/core/author | "Schmuttermaier C."xsd:string |
| http://purl.uniprot.org/citations/16357325 | http://purl.uniprot.org/core/author | "Schmuttermaier C."xsd:string |
| http://purl.uniprot.org/citations/16357325 | http://purl.uniprot.org/core/author | "Scholtze J."xsd:string |
| http://purl.uniprot.org/citations/16357325 | http://purl.uniprot.org/core/author | "Scholtze J."xsd:string |