| http://purl.uniprot.org/citations/16390825 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16390825 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16390825 | http://www.w3.org/2000/01/rdf-schema#comment | "DJ-1 is a novel oncogene and causative gene for the familial form of Parkinson's disease (PD). DJ-1 has multiple functions, including anti-oxidative stress by eliminating reactive oxygen species (ROS) and transcriptional regulation as a coactivator, and loss of these functions are thought to trigger the onset of PD. The mechanism underlying the prevention of cell death by DJ-1 is, however, not clear. In this study, we found that DJ-1 directly bound to homeodomaininteracting protein kinase 1 (HIPK1) in vitro and in vivo and that these proteins were colocalized in the nucleus. HIPK1 was then found to be degraded in human H1299 cells transfected with wild-type DJ-1 but not with a C106S DJ-1 mutant, a DJ-1 protein disrupting a catalytic domain of the putative protease, in a dose-dependent manner. Furthermore, although knockdown of either DJ-1 or HIPK1 rendered H1299 cells susceptible to H2O2-induced cell death, double-knockdown of DJ-1 and HIPK1 rendered H1299 cells resistant to H2O2-induced cell death, suggesting that the elevated level of HIPK1 induced by a low level of DJ-1 inhibits oxidative stress-induced cell death."xsd:string |
| http://purl.uniprot.org/citations/16390825 | http://purl.org/dc/terms/identifier | "doi:10.1080/10715760500456847"xsd:string |
| http://purl.uniprot.org/citations/16390825 | http://purl.org/dc/terms/identifier | "doi:10.1080/10715760500456847"xsd:string |
| http://purl.uniprot.org/citations/16390825 | http://purl.uniprot.org/core/author | "Ariga H."xsd:string |
| http://purl.uniprot.org/citations/16390825 | http://purl.uniprot.org/core/author | "Ariga H."xsd:string |
| http://purl.uniprot.org/citations/16390825 | http://purl.uniprot.org/core/author | "Niki T."xsd:string |
| http://purl.uniprot.org/citations/16390825 | http://purl.uniprot.org/core/author | "Niki T."xsd:string |
| http://purl.uniprot.org/citations/16390825 | http://purl.uniprot.org/core/author | "Iguchi-Ariga S.M.M."xsd:string |
| http://purl.uniprot.org/citations/16390825 | http://purl.uniprot.org/core/author | "Iguchi-Ariga S.M.M."xsd:string |
| http://purl.uniprot.org/citations/16390825 | http://purl.uniprot.org/core/author | "Taira T."xsd:string |
| http://purl.uniprot.org/citations/16390825 | http://purl.uniprot.org/core/author | "Taira T."xsd:string |
| http://purl.uniprot.org/citations/16390825 | http://purl.uniprot.org/core/author | "Koide-Yoshida S."xsd:string |
| http://purl.uniprot.org/citations/16390825 | http://purl.uniprot.org/core/author | "Koide-Yoshida S."xsd:string |
| http://purl.uniprot.org/citations/16390825 | http://purl.uniprot.org/core/author | "Sekito A."xsd:string |
| http://purl.uniprot.org/citations/16390825 | http://purl.uniprot.org/core/author | "Sekito A."xsd:string |
| http://purl.uniprot.org/citations/16390825 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16390825 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16390825 | http://purl.uniprot.org/core/name | "Free Radic. Res."xsd:string |
| http://purl.uniprot.org/citations/16390825 | http://purl.uniprot.org/core/name | "Free Radic. Res."xsd:string |
| http://purl.uniprot.org/citations/16390825 | http://purl.uniprot.org/core/pages | "155-165"xsd:string |
| http://purl.uniprot.org/citations/16390825 | http://purl.uniprot.org/core/pages | "155-165"xsd:string |
| http://purl.uniprot.org/citations/16390825 | http://purl.uniprot.org/core/title | "DJ-1 interacts with HIPK1 and affects H2O2-induced cell death."xsd:string |
| http://purl.uniprot.org/citations/16390825 | http://purl.uniprot.org/core/title | "DJ-1 interacts with HIPK1 and affects H2O2-induced cell death."xsd:string |