| http://purl.uniprot.org/citations/16424001 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16424001 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16424001 | http://www.w3.org/2000/01/rdf-schema#comment | "The Wnt/beta-catenin pathway has been implicated in human cancers. Here, we show that TC1 (C8orf4), a small protein present in vertebrates, functions as a positive regulator of the pathway. TC1 interacts with Chibby (Cby) and thereby enhances the signaling pathway by relieving the antagonistic function of Cby on the beta-catenin-mediated transcription. Upon coexpression in mammalian cells, TC1 redistributes from nucleolus to nuclear speckles, where it colocalizes with Cby. TC1 up-regulates the expression of beta-catenin target genes that are implicated in invasiveness and aggressive behavior of cancers, such as metalloproteinases, laminin gamma2, and others. Our data indicate that TC1 is a novel upstream regulator of the Wnt/beta-catenin pathway that enhances aggressive behavior of cancers."xsd:string |
| http://purl.uniprot.org/citations/16424001 | http://purl.org/dc/terms/identifier | "doi:10.1158/0008-5472.can-05-3124"xsd:string |
| http://purl.uniprot.org/citations/16424001 | http://purl.org/dc/terms/identifier | "doi:10.1158/0008-5472.can-05-3124"xsd:string |
| http://purl.uniprot.org/citations/16424001 | http://purl.uniprot.org/core/author | "Kim E."xsd:string |
| http://purl.uniprot.org/citations/16424001 | http://purl.uniprot.org/core/author | "Kim E."xsd:string |
| http://purl.uniprot.org/citations/16424001 | http://purl.uniprot.org/core/author | "Kim Y."xsd:string |
| http://purl.uniprot.org/citations/16424001 | http://purl.uniprot.org/core/author | "Kim Y."xsd:string |
| http://purl.uniprot.org/citations/16424001 | http://purl.uniprot.org/core/author | "Kim J."xsd:string |
| http://purl.uniprot.org/citations/16424001 | http://purl.uniprot.org/core/author | "Kim J."xsd:string |
| http://purl.uniprot.org/citations/16424001 | http://purl.uniprot.org/core/author | "Koo H."xsd:string |
| http://purl.uniprot.org/citations/16424001 | http://purl.uniprot.org/core/author | "Koo H."xsd:string |
| http://purl.uniprot.org/citations/16424001 | http://purl.uniprot.org/core/author | "Park J."xsd:string |
| http://purl.uniprot.org/citations/16424001 | http://purl.uniprot.org/core/author | "Park J."xsd:string |
| http://purl.uniprot.org/citations/16424001 | http://purl.uniprot.org/core/author | "Song K."xsd:string |
| http://purl.uniprot.org/citations/16424001 | http://purl.uniprot.org/core/author | "Song K."xsd:string |
| http://purl.uniprot.org/citations/16424001 | http://purl.uniprot.org/core/author | "Lee I."xsd:string |
| http://purl.uniprot.org/citations/16424001 | http://purl.uniprot.org/core/author | "Lee I."xsd:string |
| http://purl.uniprot.org/citations/16424001 | http://purl.uniprot.org/core/author | "Choi K."xsd:string |
| http://purl.uniprot.org/citations/16424001 | http://purl.uniprot.org/core/author | "Choi K."xsd:string |
| http://purl.uniprot.org/citations/16424001 | http://purl.uniprot.org/core/author | "Moon R.T."xsd:string |
| http://purl.uniprot.org/citations/16424001 | http://purl.uniprot.org/core/author | "Moon R.T."xsd:string |
| http://purl.uniprot.org/citations/16424001 | http://purl.uniprot.org/core/author | "Bang S."xsd:string |
| http://purl.uniprot.org/citations/16424001 | http://purl.uniprot.org/core/author | "Bang S."xsd:string |