| http://purl.uniprot.org/citations/1643658 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/1643658 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/1643658 | http://www.w3.org/2000/01/rdf-schema#comment | "The function of rac, a ras-related GTP-binding protein, was investigated in fibroblasts by microinjection. In confluent serum-starved Swiss 3T3 cells, rac1 rapidly stimulated actin filament accumulation at the plasma membrane, forming membrane ruffles. Several growth factors and activated H-ras also induced membrane ruffling, and this response was prevented by a dominant inhibitory mutant rac protein, N17rac1. This suggests that endogenous rac proteins are required for growth factor-induced membrane ruffling. In addition to membrane ruffling, a later response to both rac1 microinjection and some growth factors was the formation of actin stress fibers, a process requiring endogenous rho proteins. Using N17rac1 we have shown that these growth factors act through rac to stimulate this rho-dependent response. We propose that rac and rho are essential components of signal transduction pathways linking growth factors to the organization of polymerized actin."xsd:string |
| http://purl.uniprot.org/citations/1643658 | http://purl.org/dc/terms/identifier | "doi:10.1016/0092-8674(92)90164-8"xsd:string |
| http://purl.uniprot.org/citations/1643658 | http://purl.org/dc/terms/identifier | "doi:10.1016/0092-8674(92)90164-8"xsd:string |
| http://purl.uniprot.org/citations/1643658 | http://purl.uniprot.org/core/author | "Ridley A.J."xsd:string |
| http://purl.uniprot.org/citations/1643658 | http://purl.uniprot.org/core/author | "Ridley A.J."xsd:string |
| http://purl.uniprot.org/citations/1643658 | http://purl.uniprot.org/core/author | "Hall A."xsd:string |
| http://purl.uniprot.org/citations/1643658 | http://purl.uniprot.org/core/author | "Hall A."xsd:string |
| http://purl.uniprot.org/citations/1643658 | http://purl.uniprot.org/core/author | "Diekmann D."xsd:string |
| http://purl.uniprot.org/citations/1643658 | http://purl.uniprot.org/core/author | "Diekmann D."xsd:string |
| http://purl.uniprot.org/citations/1643658 | http://purl.uniprot.org/core/author | "Paterson H.F."xsd:string |
| http://purl.uniprot.org/citations/1643658 | http://purl.uniprot.org/core/author | "Paterson H.F."xsd:string |
| http://purl.uniprot.org/citations/1643658 | http://purl.uniprot.org/core/author | "Johnston C.L."xsd:string |
| http://purl.uniprot.org/citations/1643658 | http://purl.uniprot.org/core/author | "Johnston C.L."xsd:string |
| http://purl.uniprot.org/citations/1643658 | http://purl.uniprot.org/core/date | "1992"xsd:gYear |
| http://purl.uniprot.org/citations/1643658 | http://purl.uniprot.org/core/date | "1992"xsd:gYear |
| http://purl.uniprot.org/citations/1643658 | http://purl.uniprot.org/core/name | "Cell"xsd:string |
| http://purl.uniprot.org/citations/1643658 | http://purl.uniprot.org/core/name | "Cell"xsd:string |
| http://purl.uniprot.org/citations/1643658 | http://purl.uniprot.org/core/pages | "401-410"xsd:string |
| http://purl.uniprot.org/citations/1643658 | http://purl.uniprot.org/core/pages | "401-410"xsd:string |
| http://purl.uniprot.org/citations/1643658 | http://purl.uniprot.org/core/title | "The small GTP-binding protein rac regulates growth factor-induced membrane ruffling."xsd:string |
| http://purl.uniprot.org/citations/1643658 | http://purl.uniprot.org/core/title | "The small GTP-binding protein rac regulates growth factor-induced membrane ruffling."xsd:string |
| http://purl.uniprot.org/citations/1643658 | http://purl.uniprot.org/core/volume | "70"xsd:string |
| http://purl.uniprot.org/citations/1643658 | http://purl.uniprot.org/core/volume | "70"xsd:string |