| http://purl.uniprot.org/citations/16452507 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16452507 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16452507 | http://www.w3.org/2000/01/rdf-schema#comment | "Nonsense-mediated mRNA decay (NMD) is a surveillance mechanism that degrades mRNA containing premature termination codons (PTCs). In mammalian cells, recognition of PTCs requires translation and depends on the presence on the mRNA with the splicing-dependent exon junction complex (EJC). While it is known that a key event in the triggering of NMD is phosphorylation of the trans-acting factor, Upf1, by SMG-1, the relationship between Upf1 phosphorylation and PTC recognition remains undetermined. Here we show that SMG-1 binds to the mRNA-associated components of the EJC, Upf2, Upf3b, eIF4A3, Magoh, and Y14. Further, we describe a novel complex that contains the NMD factors SMG-1 and Upf1, and the translation termination release factors eRF1 and eRF3 (SURF). Importantly, an association between SURF and the EJC is required for SMG-1-mediated Upf1 phosphorylation and NMD. Thus, the SMG-1-mediated phosphorylation of Upf1 occurs on the association of SURF with EJC, which provides the link between the EJC and recognition of PTCs and triggers NMD."xsd:string |
| http://purl.uniprot.org/citations/16452507 | http://purl.org/dc/terms/identifier | "doi:10.1101/gad.1389006"xsd:string |
| http://purl.uniprot.org/citations/16452507 | http://purl.org/dc/terms/identifier | "doi:10.1101/gad.1389006"xsd:string |
| http://purl.uniprot.org/citations/16452507 | http://purl.uniprot.org/core/author | "Morishita R."xsd:string |
| http://purl.uniprot.org/citations/16452507 | http://purl.uniprot.org/core/author | "Morishita R."xsd:string |
| http://purl.uniprot.org/citations/16452507 | http://purl.uniprot.org/core/author | "Ohno M."xsd:string |
| http://purl.uniprot.org/citations/16452507 | http://purl.uniprot.org/core/author | "Ohno M."xsd:string |
| http://purl.uniprot.org/citations/16452507 | http://purl.uniprot.org/core/author | "Ohno S."xsd:string |
| http://purl.uniprot.org/citations/16452507 | http://purl.uniprot.org/core/author | "Ohno S."xsd:string |
| http://purl.uniprot.org/citations/16452507 | http://purl.uniprot.org/core/author | "Yamashita A."xsd:string |
| http://purl.uniprot.org/citations/16452507 | http://purl.uniprot.org/core/author | "Yamashita A."xsd:string |
| http://purl.uniprot.org/citations/16452507 | http://purl.uniprot.org/core/author | "Kashima I."xsd:string |
| http://purl.uniprot.org/citations/16452507 | http://purl.uniprot.org/core/author | "Kashima I."xsd:string |
| http://purl.uniprot.org/citations/16452507 | http://purl.uniprot.org/core/author | "Dreyfuss G."xsd:string |
| http://purl.uniprot.org/citations/16452507 | http://purl.uniprot.org/core/author | "Dreyfuss G."xsd:string |
| http://purl.uniprot.org/citations/16452507 | http://purl.uniprot.org/core/author | "Kataoka N."xsd:string |
| http://purl.uniprot.org/citations/16452507 | http://purl.uniprot.org/core/author | "Kataoka N."xsd:string |
| http://purl.uniprot.org/citations/16452507 | http://purl.uniprot.org/core/author | "Hoshino S."xsd:string |
| http://purl.uniprot.org/citations/16452507 | http://purl.uniprot.org/core/author | "Hoshino S."xsd:string |
| http://purl.uniprot.org/citations/16452507 | http://purl.uniprot.org/core/author | "Izumi N."xsd:string |
| http://purl.uniprot.org/citations/16452507 | http://purl.uniprot.org/core/author | "Izumi N."xsd:string |
| http://purl.uniprot.org/citations/16452507 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16452507 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |