| http://purl.uniprot.org/citations/16474406 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16474406 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16474406 | http://www.w3.org/2000/01/rdf-schema#comment | "Direct evidence for the requirement of transcriptional feedback repression in circadian clock function has been elusive. Here, we developed a molecular genetic screen in mammalian cells to identify mutants of the circadian transcriptional activators CLOCK and BMAL1, which were uncoupled from CRYPTOCHROME (CRY)-mediated transcriptional repression. Notably, mutations in the PER-ARNT-SIM domain of CLOCK and the C terminus of BMAL1 resulted in synergistic insensitivity through reduced physical interactions with CRY. Coexpression of these mutant proteins in cultured fibroblasts caused arrhythmic phenotypes in population and single-cell assays. These data demonstrate that CRY-mediated repression of the CLOCK/BMAL1 complex activity is required for maintenance of circadian rhythmicity and provide formal proof that transcriptional feedback is required for mammalian clock function."xsd:string |
| http://purl.uniprot.org/citations/16474406 | http://purl.org/dc/terms/identifier | "doi:10.1038/ng1745"xsd:string |
| http://purl.uniprot.org/citations/16474406 | http://purl.org/dc/terms/identifier | "doi:10.1038/ng1745"xsd:string |
| http://purl.uniprot.org/citations/16474406 | http://purl.uniprot.org/core/author | "Kay S.A."xsd:string |
| http://purl.uniprot.org/citations/16474406 | http://purl.uniprot.org/core/author | "Kay S.A."xsd:string |
| http://purl.uniprot.org/citations/16474406 | http://purl.uniprot.org/core/author | "Ueda H.R."xsd:string |
| http://purl.uniprot.org/citations/16474406 | http://purl.uniprot.org/core/author | "Ueda H.R."xsd:string |
| http://purl.uniprot.org/citations/16474406 | http://purl.uniprot.org/core/author | "Hogenesch J.B."xsd:string |
| http://purl.uniprot.org/citations/16474406 | http://purl.uniprot.org/core/author | "Hogenesch J.B."xsd:string |
| http://purl.uniprot.org/citations/16474406 | http://purl.uniprot.org/core/author | "Miraglia L.J."xsd:string |
| http://purl.uniprot.org/citations/16474406 | http://purl.uniprot.org/core/author | "Miraglia L.J."xsd:string |
| http://purl.uniprot.org/citations/16474406 | http://purl.uniprot.org/core/author | "Sato T.K."xsd:string |
| http://purl.uniprot.org/citations/16474406 | http://purl.uniprot.org/core/author | "Sato T.K."xsd:string |
| http://purl.uniprot.org/citations/16474406 | http://purl.uniprot.org/core/author | "Ukai H."xsd:string |
| http://purl.uniprot.org/citations/16474406 | http://purl.uniprot.org/core/author | "Ukai H."xsd:string |
| http://purl.uniprot.org/citations/16474406 | http://purl.uniprot.org/core/author | "Baggs J.E."xsd:string |
| http://purl.uniprot.org/citations/16474406 | http://purl.uniprot.org/core/author | "Baggs J.E."xsd:string |
| http://purl.uniprot.org/citations/16474406 | http://purl.uniprot.org/core/author | "Kobayashi T.J."xsd:string |
| http://purl.uniprot.org/citations/16474406 | http://purl.uniprot.org/core/author | "Kobayashi T.J."xsd:string |
| http://purl.uniprot.org/citations/16474406 | http://purl.uniprot.org/core/author | "Welsh D.K."xsd:string |
| http://purl.uniprot.org/citations/16474406 | http://purl.uniprot.org/core/author | "Welsh D.K."xsd:string |
| http://purl.uniprot.org/citations/16474406 | http://purl.uniprot.org/core/author | "Yamada R.G."xsd:string |
| http://purl.uniprot.org/citations/16474406 | http://purl.uniprot.org/core/author | "Yamada R.G."xsd:string |