| http://purl.uniprot.org/citations/16478993 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16478993 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16478993 | http://www.w3.org/2000/01/rdf-schema#comment | "The hsp90 chaperoning pathway is a multiprotein system that is required for the production or activation of many cell regulatory proteins, including the progesterone receptor (PR). We report here the identity of GCUNC-45 as a novel modulator of PR chaperoning by hsp90. GCUNC-45, previously implicated in the activities of myosins, can interact in vivo and in vitro with both PR-A and PR-B and with hsp90. Overexpression and knockdown experiments show GCUNC-45 to be a positive factor in promoting PR function in the cell. GCUNC-45 binds to the ATP-binding domain of hsp90 to prevent the activation of its ATPase activity by the cochaperone Aha1. This effect limits PR chaperoning by hsp90, but this can be reversed by FKBP52, a cochaperone that is thought to act later in the pathway. These findings reveal a new cochaperone binding site near the N terminus of hsp90, add insight on the role of FKBP52, and identify GCUNC-45 as a novel regulator of the PR signaling pathway."xsd:string |
| http://purl.uniprot.org/citations/16478993 | http://purl.org/dc/terms/identifier | "doi:10.1128/mcb.26.5.1722-1730.2006"xsd:string |
| http://purl.uniprot.org/citations/16478993 | http://purl.org/dc/terms/identifier | "doi:10.1128/mcb.26.5.1722-1730.2006"xsd:string |
| http://purl.uniprot.org/citations/16478993 | http://purl.uniprot.org/core/author | "Gordon D.F."xsd:string |
| http://purl.uniprot.org/citations/16478993 | http://purl.uniprot.org/core/author | "Gordon D.F."xsd:string |
| http://purl.uniprot.org/citations/16478993 | http://purl.uniprot.org/core/author | "Jackson T.A."xsd:string |
| http://purl.uniprot.org/citations/16478993 | http://purl.uniprot.org/core/author | "Jackson T.A."xsd:string |
| http://purl.uniprot.org/citations/16478993 | http://purl.uniprot.org/core/author | "Felts S.J."xsd:string |
| http://purl.uniprot.org/citations/16478993 | http://purl.uniprot.org/core/author | "Felts S.J."xsd:string |
| http://purl.uniprot.org/citations/16478993 | http://purl.uniprot.org/core/author | "Toft D."xsd:string |
| http://purl.uniprot.org/citations/16478993 | http://purl.uniprot.org/core/author | "Toft D."xsd:string |
| http://purl.uniprot.org/citations/16478993 | http://purl.uniprot.org/core/author | "Abel M.G."xsd:string |
| http://purl.uniprot.org/citations/16478993 | http://purl.uniprot.org/core/author | "Abel M.G."xsd:string |
| http://purl.uniprot.org/citations/16478993 | http://purl.uniprot.org/core/author | "Chadli A."xsd:string |
| http://purl.uniprot.org/citations/16478993 | http://purl.uniprot.org/core/author | "Chadli A."xsd:string |
| http://purl.uniprot.org/citations/16478993 | http://purl.uniprot.org/core/author | "Graham J.D."xsd:string |
| http://purl.uniprot.org/citations/16478993 | http://purl.uniprot.org/core/author | "Graham J.D."xsd:string |
| http://purl.uniprot.org/citations/16478993 | http://purl.uniprot.org/core/author | "Horwitz K.B."xsd:string |
| http://purl.uniprot.org/citations/16478993 | http://purl.uniprot.org/core/author | "Horwitz K.B."xsd:string |
| http://purl.uniprot.org/citations/16478993 | http://purl.uniprot.org/core/author | "Wood W.M."xsd:string |
| http://purl.uniprot.org/citations/16478993 | http://purl.uniprot.org/core/author | "Wood W.M."xsd:string |
| http://purl.uniprot.org/citations/16478993 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16478993 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |