| http://purl.uniprot.org/citations/16497931 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16497931 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16497931 | http://www.w3.org/2000/01/rdf-schema#comment | "The transcription factor NF-kappaB modulates apoptotic responses induced by genotoxic stress. We show that NF-kappaB essential modulator (NEMO), the regulatory subunit of IkappaB kinase (IKK) (which phosphorylates the NF-kappaB inhibitor IkappaB), associates with activated ataxia telangiectasia mutated (ATM) after the induction of DNA double-strand breaks. ATM phosphorylates serine-85 of NEMO to promote its ubiquitin-dependent nuclear export. ATM is also exported in a NEMO-dependent manner to the cytoplasm, where it associates with and causes the activation of IKK in a manner dependent on another IKK regulator, a protein rich in glutamate, leucine, lysine, and serine (ELKS). Thus, regulated nuclear shuttling of NEMO links two signaling kinases, ATM and IKK, to activate NF-kappaB by genotoxic signals."xsd:string |
| http://purl.uniprot.org/citations/16497931 | http://purl.org/dc/terms/identifier | "doi:10.1126/science.1121513"xsd:string |
| http://purl.uniprot.org/citations/16497931 | http://purl.org/dc/terms/identifier | "doi:10.1126/science.1121513"xsd:string |
| http://purl.uniprot.org/citations/16497931 | http://purl.uniprot.org/core/author | "Shi Y."xsd:string |
| http://purl.uniprot.org/citations/16497931 | http://purl.uniprot.org/core/author | "Shi Y."xsd:string |
| http://purl.uniprot.org/citations/16497931 | http://purl.uniprot.org/core/author | "Wu Z.H."xsd:string |
| http://purl.uniprot.org/citations/16497931 | http://purl.uniprot.org/core/author | "Wu Z.H."xsd:string |
| http://purl.uniprot.org/citations/16497931 | http://purl.uniprot.org/core/author | "Miyamoto S."xsd:string |
| http://purl.uniprot.org/citations/16497931 | http://purl.uniprot.org/core/author | "Miyamoto S."xsd:string |
| http://purl.uniprot.org/citations/16497931 | http://purl.uniprot.org/core/author | "Tibbetts R.S."xsd:string |
| http://purl.uniprot.org/citations/16497931 | http://purl.uniprot.org/core/author | "Tibbetts R.S."xsd:string |
| http://purl.uniprot.org/citations/16497931 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16497931 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16497931 | http://purl.uniprot.org/core/name | "Science"xsd:string |
| http://purl.uniprot.org/citations/16497931 | http://purl.uniprot.org/core/name | "Science"xsd:string |
| http://purl.uniprot.org/citations/16497931 | http://purl.uniprot.org/core/pages | "1141-1146"xsd:string |
| http://purl.uniprot.org/citations/16497931 | http://purl.uniprot.org/core/pages | "1141-1146"xsd:string |
| http://purl.uniprot.org/citations/16497931 | http://purl.uniprot.org/core/title | "Molecular linkage between the kinase ATM and NF-kappaB signaling in response to genotoxic stimuli."xsd:string |
| http://purl.uniprot.org/citations/16497931 | http://purl.uniprot.org/core/title | "Molecular linkage between the kinase ATM and NF-kappaB signaling in response to genotoxic stimuli."xsd:string |
| http://purl.uniprot.org/citations/16497931 | http://purl.uniprot.org/core/volume | "311"xsd:string |
| http://purl.uniprot.org/citations/16497931 | http://purl.uniprot.org/core/volume | "311"xsd:string |
| http://purl.uniprot.org/citations/16497931 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/16497931 |
| http://purl.uniprot.org/citations/16497931 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/16497931 |