| http://purl.uniprot.org/citations/16540568 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16540568 | http://www.w3.org/2000/01/rdf-schema#comment | "Abnormal function of NMDA receptor has been suggested to be correlated with the pathogenesis of Parkinson's disease (PD) as well as with the development of l-3,4-dihydroxyphenylalanine (L-DOPA)-induced dyskinesia. Here we show that NMDA receptor NR2 subunits display specific alterations of their subcellular distribution in striata from unilateral 6-hydroxydopamine-lesioned, L-DOPA-treated dyskinetic, and L-DOPA-treated nondyskinetic rats. Dyskinetic animals have significantly higher levels of NR2A subunit in the postsynaptic compartment than all other experimental groups, whereas NR2B subunit shows a significant reduction in both dopamine-denervated and dyskinetic rats. These events are paralleled by profound modifications of NMDA receptor NR2B subunit association with interacting elements, i.e., members of the membrane-associated guanylate kinase (MAGUK) protein family postsynaptic density-95, synapse-associated protein-97 and synapse-associated protein-102. Treatment of nondyskinetic animals with a synthetic peptide (TAT2B) able to affect NR2B binding to MAGUK proteins as well as synaptic localization of this subunit in nondyskinetic rats was sufficient to induce a shift of treated rats toward a dyskinetic motor behavior. These data indicate abnormal NR2B redistribution between synaptic and extrasynaptic membranes as an important molecular disturbance of the glutamatergic synapse involved in L-DOPA-induced dyskinesia."xsd:string |
| http://purl.uniprot.org/citations/16540568 | http://purl.org/dc/terms/identifier | "doi:10.1523/jneurosci.5326-05.2006"xsd:string |
| http://purl.uniprot.org/citations/16540568 | http://purl.uniprot.org/core/author | "Di Luca M."xsd:string |
| http://purl.uniprot.org/citations/16540568 | http://purl.uniprot.org/core/author | "Gardoni F."xsd:string |
| http://purl.uniprot.org/citations/16540568 | http://purl.uniprot.org/core/author | "Bernardi G."xsd:string |
| http://purl.uniprot.org/citations/16540568 | http://purl.uniprot.org/core/author | "Calabresi P."xsd:string |
| http://purl.uniprot.org/citations/16540568 | http://purl.uniprot.org/core/author | "Cattabeni F."xsd:string |
| http://purl.uniprot.org/citations/16540568 | http://purl.uniprot.org/core/author | "Picconi B."xsd:string |
| http://purl.uniprot.org/citations/16540568 | http://purl.uniprot.org/core/author | "Bagetta V."xsd:string |
| http://purl.uniprot.org/citations/16540568 | http://purl.uniprot.org/core/author | "Ghiglieri V."xsd:string |
| http://purl.uniprot.org/citations/16540568 | http://purl.uniprot.org/core/author | "Polli F."xsd:string |
| http://purl.uniprot.org/citations/16540568 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16540568 | http://purl.uniprot.org/core/name | "J Neurosci"xsd:string |
| http://purl.uniprot.org/citations/16540568 | http://purl.uniprot.org/core/pages | "2914-2922"xsd:string |
| http://purl.uniprot.org/citations/16540568 | http://purl.uniprot.org/core/title | "A critical interaction between NR2B and MAGUK in L-DOPA induced dyskinesia."xsd:string |
| http://purl.uniprot.org/citations/16540568 | http://purl.uniprot.org/core/volume | "26"xsd:string |
| http://purl.uniprot.org/citations/16540568 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/16540568 |
| http://purl.uniprot.org/citations/16540568 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/16540568 |
| http://purl.uniprot.org/uniprot/P31016#attribution-B4CA73DBFCACEBBE0DADFEA9688669DD | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/16540568 |
| http://purl.uniprot.org/uniprot/Q62696#attribution-B4CA73DBFCACEBBE0DADFEA9688669DD | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/16540568 |
| http://purl.uniprot.org/uniprot/Q62936#attribution-B4CA73DBFCACEBBE0DADFEA9688669DD | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/16540568 |
| http://purl.uniprot.org/uniprot/Q00960#attribution-B4CA73DBFCACEBBE0DADFEA9688669DD | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/16540568 |
| http://purl.uniprot.org/uniprot/Q00959#attribution-B4CA73DBFCACEBBE0DADFEA9688669DD | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/16540568 |
| http://purl.uniprot.org/uniprot/#_A0A0G2K7F5-mappedCitation-16540568 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16540568 |