| http://purl.uniprot.org/citations/16547100 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16547100 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16547100 | http://www.w3.org/2000/01/rdf-schema#comment | "Previous genetic analysis has shown that dos/soc-1/Gab1 functions positively in receptor tyrosine kinase (RTK)-stimulated Ras/Map kinase signaling through the recruitment of csw/ptp-2/Shp2. Using sensitized assays in Caenorhabditis elegans for let-23/Egfr and daf-2/InsR (insulin receptor-like) signaling, it is shown that soc-1/Gab1 inhibits phospholipase C-gamma (PLCgamma) and phosphatidylinositol 3'-kinase (PI3K)-mediated signaling. Furthermore, as well as stimulating Ras/Map kinase signaling, soc-1/Gab1 stimulates a poorly defined signaling pathway that represses class 2 daf-2 phenotypes. In addition, it is shown that SOC-1 binds the C-terminal SH3 domain of SEM-5. This binding is likely to be functional as the sem-5(n2195)G201R mutation, which disrupts SOC-1 binding, behaves in a qualitatively similar manner to a soc-1 null allele in all assays for let-23/Egfr and daf-2/InsR signaling that were examined. Further genetic analysis suggests that ptp-2/Shp2 mediates the negative function of soc-1/Gab1 in PI3K-mediated signaling, as well as the positive function in Ras/Map kinase signaling. Other effectors of soc-1/Gab1 are likely to inhibit PLCgamma-mediated signaling and stimulate the poorly defined signaling pathway that represses class 2 daf-2 phenotypes. Thus, the recruitment of soc-1/Gab1, and its effectors, into the RTK-signaling complex modifies the cellular response by enhancing Ras/Map kinase signaling while inhibiting PI3K and PLCgamma-mediated signaling."xsd:string |
| http://purl.uniprot.org/citations/16547100 | http://purl.org/dc/terms/identifier | "doi:10.1534/genetics.106.055822"xsd:string |
| http://purl.uniprot.org/citations/16547100 | http://purl.org/dc/terms/identifier | "doi:10.1534/genetics.106.055822"xsd:string |
| http://purl.uniprot.org/citations/16547100 | http://purl.uniprot.org/core/author | "Hopper N.A."xsd:string |
| http://purl.uniprot.org/citations/16547100 | http://purl.uniprot.org/core/author | "Hopper N.A."xsd:string |
| http://purl.uniprot.org/citations/16547100 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16547100 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16547100 | http://purl.uniprot.org/core/name | "Genetics"xsd:string |
| http://purl.uniprot.org/citations/16547100 | http://purl.uniprot.org/core/name | "Genetics"xsd:string |
| http://purl.uniprot.org/citations/16547100 | http://purl.uniprot.org/core/pages | "163-175"xsd:string |
| http://purl.uniprot.org/citations/16547100 | http://purl.uniprot.org/core/pages | "163-175"xsd:string |
| http://purl.uniprot.org/citations/16547100 | http://purl.uniprot.org/core/title | "The adaptor protein soc-1/Gab1 modifies growth factor receptor output in Caenorhabditis elegans."xsd:string |
| http://purl.uniprot.org/citations/16547100 | http://purl.uniprot.org/core/title | "The adaptor protein soc-1/Gab1 modifies growth factor receptor output in Caenorhabditis elegans."xsd:string |
| http://purl.uniprot.org/citations/16547100 | http://purl.uniprot.org/core/volume | "173"xsd:string |
| http://purl.uniprot.org/citations/16547100 | http://purl.uniprot.org/core/volume | "173"xsd:string |
| http://purl.uniprot.org/citations/16547100 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/16547100 |
| http://purl.uniprot.org/citations/16547100 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/16547100 |
| http://purl.uniprot.org/citations/16547100 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/16547100 |
| http://purl.uniprot.org/citations/16547100 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/16547100 |
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| http://purl.uniprot.org/uniprot/P29355 | http://purl.uniprot.org/core/citation | http://purl.uniprot.org/citations/16547100 |
| http://purl.uniprot.org/uniprot/G5EC24#attribution-D7606B1623F67CA4A9D120648070670C | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/16547100 |