| http://purl.uniprot.org/citations/16582008 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16582008 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16582008 | http://www.w3.org/2000/01/rdf-schema#comment | "The aryl hydrocarbon receptor (AHR) is a ligand-activated transcription factor with important roles in metabolic adaptation, dioxin toxicology, and vascular development. To understand the details of this signal transduction pathway, we have used the yeast two-hybrid system to identify proteins that physically interact with the AHR in a ligand-dependent manner. Using this strategy, we identified a novel modifier of the AHR signaling pathway that we named Ah-receptor associated protein 3 (ARA3). Coexpression of ARA3 with an AHR chimera in yeast and mammalian cells enhances signaling in response to agonists. The human full-length cDNA previously was described as influenza virus nonstructural protein-1 binding protein (NS1BP). This protein contains four apparent domains-a "broad complex/tramtrack/bric-a-brac" (BTB) domain, a "kelch" domain, a "BTB and C-terminal kelch" (BACK) domain, and an intervening region (IVR). The carboxyl terminus of the AHR "Per-ARNT-Sim" (periodicity/AHR nuclear translocator/simple-minded) domain and the BACK/IVR domains of ARA3 mediate the AHR-ARA3 interaction. The BACK/IVR domains of ARA3 also are sufficient to modify AHR signaling in yeast and mammalian cells. In an effort to provide a preliminary model of NS1BP activity in AHR signaling, we demonstrate that NS1BP regulates the concentration of functional AHR in mammalian cells."xsd:string |
| http://purl.uniprot.org/citations/16582008 | http://purl.org/dc/terms/identifier | "doi:10.1124/mol.106.024380"xsd:string |
| http://purl.uniprot.org/citations/16582008 | http://purl.org/dc/terms/identifier | "doi:10.1124/mol.106.024380"xsd:string |
| http://purl.uniprot.org/citations/16582008 | http://purl.uniprot.org/core/author | "Bradfield C.A."xsd:string |
| http://purl.uniprot.org/citations/16582008 | http://purl.uniprot.org/core/author | "Bradfield C.A."xsd:string |
| http://purl.uniprot.org/citations/16582008 | http://purl.uniprot.org/core/author | "Dunham E.E."xsd:string |
| http://purl.uniprot.org/citations/16582008 | http://purl.uniprot.org/core/author | "Dunham E.E."xsd:string |
| http://purl.uniprot.org/citations/16582008 | http://purl.uniprot.org/core/author | "Glover E."xsd:string |
| http://purl.uniprot.org/citations/16582008 | http://purl.uniprot.org/core/author | "Glover E."xsd:string |
| http://purl.uniprot.org/citations/16582008 | http://purl.uniprot.org/core/author | "Stevens E.A."xsd:string |
| http://purl.uniprot.org/citations/16582008 | http://purl.uniprot.org/core/author | "Stevens E.A."xsd:string |
| http://purl.uniprot.org/citations/16582008 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16582008 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16582008 | http://purl.uniprot.org/core/name | "Mol. Pharmacol."xsd:string |
| http://purl.uniprot.org/citations/16582008 | http://purl.uniprot.org/core/name | "Mol. Pharmacol."xsd:string |
| http://purl.uniprot.org/citations/16582008 | http://purl.uniprot.org/core/pages | "8-15"xsd:string |
| http://purl.uniprot.org/citations/16582008 | http://purl.uniprot.org/core/pages | "8-15"xsd:string |
| http://purl.uniprot.org/citations/16582008 | http://purl.uniprot.org/core/title | "The aryl hydrocarbon receptor signaling pathway is modified through interactions with a Kelch protein."xsd:string |
| http://purl.uniprot.org/citations/16582008 | http://purl.uniprot.org/core/title | "The aryl hydrocarbon receptor signaling pathway is modified through interactions with a Kelch protein."xsd:string |
| http://purl.uniprot.org/citations/16582008 | http://purl.uniprot.org/core/volume | "70"xsd:string |
| http://purl.uniprot.org/citations/16582008 | http://purl.uniprot.org/core/volume | "70"xsd:string |
| http://purl.uniprot.org/citations/16582008 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/16582008 |
| http://purl.uniprot.org/citations/16582008 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/16582008 |