| http://purl.uniprot.org/citations/16582099 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16582099 | http://www.w3.org/2000/01/rdf-schema#comment | "Sox proteins are widely believed to team up with other transcription factors as partner proteins to perform their many essential functions during development. In this study, yeast two-hybrid screens identified transcription factors as a major group of interacting proteins for Sox8 and Sox10. Interacting transcription factors were very similar for these two group E Sox proteins and included proteins with different types of DNA-binding domains, such as homeodomain proteins, zinc finger proteins, basic helix-loop-helix and leucine zipper proteins. In all cases analyzed, the interaction involved the DNA-binding domain of the transcription factor which directly contacted the C-terminal part of the high-mobility-group (HMG) domain. In particular, the C-terminal tail region behind helix 3 of the HMG domain was shown by mutagenesis to be essential for interaction and transcription factor recruitment. The HMG domain thus not only possesses DNA-binding and DNA-bending but also protein-interacting ability which may be equally important for the architectural function of Sox proteins on their target gene promoters."xsd:string |
| http://purl.uniprot.org/citations/16582099 | http://purl.org/dc/terms/identifier | "doi:10.1093/nar/gkl105"xsd:string |
| http://purl.uniprot.org/citations/16582099 | http://purl.uniprot.org/core/author | "Wegner M."xsd:string |
| http://purl.uniprot.org/citations/16582099 | http://purl.uniprot.org/core/author | "Wolf M."xsd:string |
| http://purl.uniprot.org/citations/16582099 | http://purl.uniprot.org/core/author | "Kosian T."xsd:string |
| http://purl.uniprot.org/citations/16582099 | http://purl.uniprot.org/core/author | "Finzsch M."xsd:string |
| http://purl.uniprot.org/citations/16582099 | http://purl.uniprot.org/core/author | "Wissmuller S."xsd:string |
| http://purl.uniprot.org/citations/16582099 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16582099 | http://purl.uniprot.org/core/name | "Nucleic Acids Res"xsd:string |
| http://purl.uniprot.org/citations/16582099 | http://purl.uniprot.org/core/pages | "1735-1744"xsd:string |
| http://purl.uniprot.org/citations/16582099 | http://purl.uniprot.org/core/title | "The high-mobility-group domain of Sox proteins interacts with DNA-binding domains of many transcription factors."xsd:string |
| http://purl.uniprot.org/citations/16582099 | http://purl.uniprot.org/core/volume | "34"xsd:string |
| http://purl.uniprot.org/citations/16582099 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/16582099 |
| http://purl.uniprot.org/citations/16582099 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/16582099 |
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| http://purl.uniprot.org/uniprot/P70396#attribution-79C9EBAD60198BA74384AE29FDD67AC0 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/16582099 |
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