| http://purl.uniprot.org/citations/16678101 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16678101 | http://www.w3.org/2000/01/rdf-schema#comment | "While the biological roles of canonical Wnt/beta-catenin signaling in development and disease are well documented, understanding the molecular logic underlying the functionally distinct nuclear transcriptional programs mediating the diverse functions of beta-catenin remains a major challenge. Here, we report an unexpected strategy for beta-catenin-dependent regulation of cell-lineage determination based on interactions between beta-catenin and a specific homeodomain factor, Prop1, rather than Lef/Tcfs. beta-catenin acts as a binary switch to simultaneously activate expression of the critical lineage-determining transcription factor, Pit1, and to repress the gene encoding the lineage-inhibiting transcription factor, Hesx1, acting via TLE/Reptin/HDAC1 corepressor complexes. The strategy of functionally distinct actions of a homeodomain factor in response to Wnt signaling is suggested to be prototypic of a widely used mechanism for generating diverse cell types from pluripotent precursor cells in response to common signaling pathways during organogenesis."xsd:string |
| http://purl.uniprot.org/citations/16678101 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.cell.2006.02.046"xsd:string |
| http://purl.uniprot.org/citations/16678101 | http://purl.uniprot.org/core/author | "Li X."xsd:string |
| http://purl.uniprot.org/citations/16678101 | http://purl.uniprot.org/core/author | "Zhang J."xsd:string |
| http://purl.uniprot.org/citations/16678101 | http://purl.uniprot.org/core/author | "Wu W."xsd:string |
| http://purl.uniprot.org/citations/16678101 | http://purl.uniprot.org/core/author | "Rosenfeld M.G."xsd:string |
| http://purl.uniprot.org/citations/16678101 | http://purl.uniprot.org/core/author | "Taketo M.M."xsd:string |
| http://purl.uniprot.org/citations/16678101 | http://purl.uniprot.org/core/author | "Ohgi K.A."xsd:string |
| http://purl.uniprot.org/citations/16678101 | http://purl.uniprot.org/core/author | "Grosschedl R."xsd:string |
| http://purl.uniprot.org/citations/16678101 | http://purl.uniprot.org/core/author | "Kemler R."xsd:string |
| http://purl.uniprot.org/citations/16678101 | http://purl.uniprot.org/core/author | "Krones A."xsd:string |
| http://purl.uniprot.org/citations/16678101 | http://purl.uniprot.org/core/author | "Rose D."xsd:string |
| http://purl.uniprot.org/citations/16678101 | http://purl.uniprot.org/core/author | "Scafoglio C."xsd:string |
| http://purl.uniprot.org/citations/16678101 | http://purl.uniprot.org/core/author | "Tollkuhn J."xsd:string |
| http://purl.uniprot.org/citations/16678101 | http://purl.uniprot.org/core/author | "Olson L.E."xsd:string |
| http://purl.uniprot.org/citations/16678101 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16678101 | http://purl.uniprot.org/core/name | "Cell"xsd:string |
| http://purl.uniprot.org/citations/16678101 | http://purl.uniprot.org/core/pages | "593-605"xsd:string |
| http://purl.uniprot.org/citations/16678101 | http://purl.uniprot.org/core/title | "Homeodomain-mediated beta-catenin-dependent switching events dictate cell-lineage determination."xsd:string |
| http://purl.uniprot.org/citations/16678101 | http://purl.uniprot.org/core/volume | "125"xsd:string |
| http://purl.uniprot.org/citations/16678101 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/16678101 |
| http://purl.uniprot.org/citations/16678101 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/16678101 |
| http://purl.uniprot.org/uniprot/Q02248#attribution-D5CC5D15C3D953035531E1D2C6304978 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/16678101 |
| http://purl.uniprot.org/uniprot/O09106#attribution-D5CC5D15C3D953035531E1D2C6304978 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/16678101 |