| http://purl.uniprot.org/citations/16682945 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16682945 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16682945 | http://www.w3.org/2000/01/rdf-schema#comment | "The transmembrane protein-tyrosine phosphatase (PTP) DEP-1 (density-enhanced phosphatase) is a candidate tumor suppressor in the colon epithelium. We have explored the function of DEP-1 in colon epithelial cells by inducible re-expression in a DEP-1-deficient human colon cancer cell line. Density-enhanced phosphatase-1 re-expression led to profound inhibition of cell proliferation and cell migration, and was associated with cytoskeletal rearrangements. These effects were dependent on the PTP activity of DEP-1 as they were not observed with cells expressing the catalytically inactive DEP-1 C1239S variant. shRNA-mediated suppression of DEP-1 in a colon epithelial cell line with high endogenous DEP-1 levels enhanced proliferation, further supporting the antiproliferative function of DEP-1. Nutrients, which are considered to be chemoprotective with respect to colon cancer development, including butyrate, green tea and apple polyphenols, had the capacity to elevate transcription of endogenous DEP-1 mRNA and expression of DEP-1 protein. Upregulation of DEP-1 expression, and in turn inhibition of cell growth and migration may present a previously unrecognized mechanism of chemoprevention by nutrients."xsd:string |
| http://purl.uniprot.org/citations/16682945 | http://purl.org/dc/terms/identifier | "doi:10.1038/sj.onc.1209647"xsd:string |
| http://purl.uniprot.org/citations/16682945 | http://purl.org/dc/terms/identifier | "doi:10.1038/sj.onc.1209647"xsd:string |
| http://purl.uniprot.org/citations/16682945 | http://purl.uniprot.org/core/author | "Bohmer F.D."xsd:string |
| http://purl.uniprot.org/citations/16682945 | http://purl.uniprot.org/core/author | "Bohmer F.D."xsd:string |
| http://purl.uniprot.org/citations/16682945 | http://purl.uniprot.org/core/author | "Friedrich K."xsd:string |
| http://purl.uniprot.org/citations/16682945 | http://purl.uniprot.org/core/author | "Friedrich K."xsd:string |
| http://purl.uniprot.org/citations/16682945 | http://purl.uniprot.org/core/author | "Ostman A."xsd:string |
| http://purl.uniprot.org/citations/16682945 | http://purl.uniprot.org/core/author | "Ostman A."xsd:string |
| http://purl.uniprot.org/citations/16682945 | http://purl.uniprot.org/core/author | "Jandt E."xsd:string |
| http://purl.uniprot.org/citations/16682945 | http://purl.uniprot.org/core/author | "Jandt E."xsd:string |
| http://purl.uniprot.org/citations/16682945 | http://purl.uniprot.org/core/author | "Balavenkatraman K.K."xsd:string |
| http://purl.uniprot.org/citations/16682945 | http://purl.uniprot.org/core/author | "Balavenkatraman K.K."xsd:string |
| http://purl.uniprot.org/citations/16682945 | http://purl.uniprot.org/core/author | "Kautenburger T."xsd:string |
| http://purl.uniprot.org/citations/16682945 | http://purl.uniprot.org/core/author | "Kautenburger T."xsd:string |
| http://purl.uniprot.org/citations/16682945 | http://purl.uniprot.org/core/author | "Pool-Zobel B.L."xsd:string |
| http://purl.uniprot.org/citations/16682945 | http://purl.uniprot.org/core/author | "Pool-Zobel B.L."xsd:string |
| http://purl.uniprot.org/citations/16682945 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16682945 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16682945 | http://purl.uniprot.org/core/name | "Oncogene"xsd:string |
| http://purl.uniprot.org/citations/16682945 | http://purl.uniprot.org/core/name | "Oncogene"xsd:string |
| http://purl.uniprot.org/citations/16682945 | http://purl.uniprot.org/core/pages | "6319-6324"xsd:string |
| http://purl.uniprot.org/citations/16682945 | http://purl.uniprot.org/core/pages | "6319-6324"xsd:string |