| http://purl.uniprot.org/citations/16684768 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16684768 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16684768 | http://www.w3.org/2000/01/rdf-schema#comment | "Nuclear factor kappaB (NF-kappaB) plays a pivotal role in inflammation, immunity, stress responses, and protection from apoptosis. Canonical activation of NF-kappaB is dependent on the phosphorylation of the inhibitory subunit IkappaBalpha that is mediated by a multimeric, high molecular weight complex, called IkappaB kinase (IKK) complex. This is composed of two catalytic subunits, IKKalpha and IKKbeta, and a regulatory subunit, NEMO/IKKgamma. The latter protein is essential for the activation of IKKs and NF-kappaB, but its mechanism of action is not well understood. Here we identified ABIN-1 (A20 binding inhibitor of NF-kappaB) as a NEMO/IKKgamma-interacting protein. ABIN-1 has been previously identified as an A20-binding protein and it has been proposed to mediate the NF-kappaB inhibiting effects of A20. We find that both ABIN-1 and A20 inhibit NF-kappaB at the level of the IKK complex and that A20 inhibits activation of NF-kappaB by de-ubiquitination of NEMO/IKKgamma. Importantly, small interfering RNA targeting ABIN-1 abrogates A20-dependent de-ubiquitination of NEMO/IKKgamma and RNA interference of A20 impairs the ability of ABIN-1 to inhibit NF-kappaB activation. Altogether our data indicate that ABIN-1 physically links A20 to NEMO/IKKgamma and facilitates A20-mediated de-ubiquitination of NEMO/IKKgamma, thus resulting in inhibition of NF-kappaB."xsd:string |
| http://purl.uniprot.org/citations/16684768 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m601502200"xsd:string |
| http://purl.uniprot.org/citations/16684768 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m601502200"xsd:string |
| http://purl.uniprot.org/citations/16684768 | http://purl.uniprot.org/core/author | "Formisano S."xsd:string |
| http://purl.uniprot.org/citations/16684768 | http://purl.uniprot.org/core/author | "Formisano S."xsd:string |
| http://purl.uniprot.org/citations/16684768 | http://purl.uniprot.org/core/author | "Vito P."xsd:string |
| http://purl.uniprot.org/citations/16684768 | http://purl.uniprot.org/core/author | "Vito P."xsd:string |
| http://purl.uniprot.org/citations/16684768 | http://purl.uniprot.org/core/author | "Leonardi A."xsd:string |
| http://purl.uniprot.org/citations/16684768 | http://purl.uniprot.org/core/author | "Leonardi A."xsd:string |
| http://purl.uniprot.org/citations/16684768 | http://purl.uniprot.org/core/author | "Mauro C."xsd:string |
| http://purl.uniprot.org/citations/16684768 | http://purl.uniprot.org/core/author | "Mauro C."xsd:string |
| http://purl.uniprot.org/citations/16684768 | http://purl.uniprot.org/core/author | "Acquaviva R."xsd:string |
| http://purl.uniprot.org/citations/16684768 | http://purl.uniprot.org/core/author | "Acquaviva R."xsd:string |
| http://purl.uniprot.org/citations/16684768 | http://purl.uniprot.org/core/author | "Iannetti A."xsd:string |
| http://purl.uniprot.org/citations/16684768 | http://purl.uniprot.org/core/author | "Iannetti A."xsd:string |
| http://purl.uniprot.org/citations/16684768 | http://purl.uniprot.org/core/author | "Lavorgna A."xsd:string |
| http://purl.uniprot.org/citations/16684768 | http://purl.uniprot.org/core/author | "Lavorgna A."xsd:string |
| http://purl.uniprot.org/citations/16684768 | http://purl.uniprot.org/core/author | "Mellone S."xsd:string |
| http://purl.uniprot.org/citations/16684768 | http://purl.uniprot.org/core/author | "Mellone S."xsd:string |
| http://purl.uniprot.org/citations/16684768 | http://purl.uniprot.org/core/author | "Pacifico F."xsd:string |
| http://purl.uniprot.org/citations/16684768 | http://purl.uniprot.org/core/author | "Pacifico F."xsd:string |
| http://purl.uniprot.org/citations/16684768 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16684768 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |