| http://purl.uniprot.org/citations/16690027 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16690027 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16690027 | http://www.w3.org/2000/01/rdf-schema#comment | "Transforming growth factor-beta (TGF-beta) is the prototypical member of a family of growth factors that play important roles in normal development and human diseases. We identified the gene for fibroblast growth factor-binding protein 1 (FGF-BP1) as being significantly repressed following TGF-beta treatment. FGF-BP1 is an extracellular matrix bound protein that enhances fibroblast growth factor (FGF) signaling. We demonstrate here that TGF-beta signaling significantly represses FGF-BP1 expression in mesenchymal and neural crest cells undergoing in vitro smooth muscle differentiation. Analysis of the downstream signaling pathways shows that Smad2/3 are crucial for efficient FGF-BP1 repression by TGF-beta. Furthermore, we identified a novel element in the region from -785 to -782 bp of the FGF-BP1 promoter, which represents a known binding site for Hypermethylation in Cancer-1 (Hic-1), necessary for repression of FGF-BP1 by TGF-beta. These data define the molecular mechanism of transcriptional repression of an important target of TGF-beta signaling during angiogenesis."xsd:string |
| http://purl.uniprot.org/citations/16690027 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.bbrc.2006.04.052"xsd:string |
| http://purl.uniprot.org/citations/16690027 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.bbrc.2006.04.052"xsd:string |
| http://purl.uniprot.org/citations/16690027 | http://purl.uniprot.org/core/author | "Chen S."xsd:string |
| http://purl.uniprot.org/citations/16690027 | http://purl.uniprot.org/core/author | "Chen S."xsd:string |
| http://purl.uniprot.org/citations/16690027 | http://purl.uniprot.org/core/author | "Riegel A.T."xsd:string |
| http://purl.uniprot.org/citations/16690027 | http://purl.uniprot.org/core/author | "Riegel A.T."xsd:string |
| http://purl.uniprot.org/citations/16690027 | http://purl.uniprot.org/core/author | "Lechleider R.J."xsd:string |
| http://purl.uniprot.org/citations/16690027 | http://purl.uniprot.org/core/author | "Lechleider R.J."xsd:string |
| http://purl.uniprot.org/citations/16690027 | http://purl.uniprot.org/core/author | "Briones V.R."xsd:string |
| http://purl.uniprot.org/citations/16690027 | http://purl.uniprot.org/core/author | "Briones V.R."xsd:string |
| http://purl.uniprot.org/citations/16690027 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16690027 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16690027 | http://purl.uniprot.org/core/name | "Biochem. Biophys. Res. Commun."xsd:string |
| http://purl.uniprot.org/citations/16690027 | http://purl.uniprot.org/core/name | "Biochem. Biophys. Res. Commun."xsd:string |
| http://purl.uniprot.org/citations/16690027 | http://purl.uniprot.org/core/pages | "595-601"xsd:string |
| http://purl.uniprot.org/citations/16690027 | http://purl.uniprot.org/core/pages | "595-601"xsd:string |
| http://purl.uniprot.org/citations/16690027 | http://purl.uniprot.org/core/title | "Mechanism of fibroblast growth factor-binding protein 1 repression by TGF-beta."xsd:string |
| http://purl.uniprot.org/citations/16690027 | http://purl.uniprot.org/core/title | "Mechanism of fibroblast growth factor-binding protein 1 repression by TGF-beta."xsd:string |
| http://purl.uniprot.org/citations/16690027 | http://purl.uniprot.org/core/volume | "345"xsd:string |
| http://purl.uniprot.org/citations/16690027 | http://purl.uniprot.org/core/volume | "345"xsd:string |
| http://purl.uniprot.org/citations/16690027 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/16690027 |
| http://purl.uniprot.org/citations/16690027 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/16690027 |