RDF/XMLNTriplesTurtleShow queryShare
SubjectPredicateObject
http://purl.uniprot.org/citations/16716898http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/16716898http://www.w3.org/2000/01/rdf-schema#comment"Previous studies have shown that transgenic mice overexpressing Cu/Zn superoxide dismutase, a model of Down syndrome, exhibit premature thymic involution. We have performed a flow cytometry analysis of the developing thymus in these homozygous transgenic mice (hSOD1/hSOD1: Tg-SOD). Longitudinal follow-up analysis from day 3 to day 280 showed an early thymic development in Tg-SOD mice compared with controls. This early thymic development was associated with an increased migration of mature T cells to peripheral lymphoid organs. BrdU labeling showed no difference between Tg-SOD and control mice, confirming that the greater number of peripheral T cells in Tg-SOD mice was not due to extensive proliferation of these cells but rather to a greater pool of emigrant T cells in Tg-SOD."xsd:string
http://purl.uniprot.org/citations/16716898http://purl.org/dc/terms/identifier"doi:10.1016/j.freeradbiomed.2006.01.029"xsd:string
http://purl.uniprot.org/citations/16716898http://purl.uniprot.org/core/author"Laurent J."xsd:string
http://purl.uniprot.org/citations/16716898http://purl.uniprot.org/core/author"London J."xsd:string
http://purl.uniprot.org/citations/16716898http://purl.uniprot.org/core/author"Paly E."xsd:string
http://purl.uniprot.org/citations/16716898http://purl.uniprot.org/core/author"Marche P.N."xsd:string
http://purl.uniprot.org/citations/16716898http://purl.uniprot.org/core/date"2006"xsd:gYear
http://purl.uniprot.org/citations/16716898http://purl.uniprot.org/core/name"Free Radic Biol Med"xsd:string
http://purl.uniprot.org/citations/16716898http://purl.uniprot.org/core/pages"1971-1980"xsd:string
http://purl.uniprot.org/citations/16716898http://purl.uniprot.org/core/title"Early thymic T cell development in young transgenic mice overexpressing human Cu/Zn superoxide dismutase, a model of Down syndrome."xsd:string
http://purl.uniprot.org/citations/16716898http://purl.uniprot.org/core/volume"40"xsd:string
http://purl.uniprot.org/citations/16716898http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/16716898
http://purl.uniprot.org/citations/16716898http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/16716898
http://purl.uniprot.org/uniprot/P00441#attribution-4D529DC52989AFFE16865E75A0B525EAhttp://purl.uniprot.org/core/sourcehttp://purl.uniprot.org/citations/16716898