| http://purl.uniprot.org/citations/16717086 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16717086 | http://www.w3.org/2000/01/rdf-schema#comment | "Anti-apoptotic activity of BCL-2 is mediated by phosphorylation at the endoplasmic reticulum (ER), but how this phosphorylation is regulated and the mechanism(s) by which it regulates apoptosis are unknown. We purified macromolecular complexes containing BCL-2 from ER membranes and found that BCL-2 co-purified with the main two subunits of the serine/threonine phosphatase, PP2A. The association of endogenous PP2A and BCL-2 at the ER was verified by co-immunoprecipitation and microcystin affinity purification. Knock down or pharmacological inhibition of PP2A caused degradation of phosphorylated BCL-2 and led to an overall reduction in BCL-2 levels. We found that this degradation was due to the action of the proteasome acting selectively at the ER. Conversely, overexpression of PP2A caused elevation in endogenous BCL-2. Most importantly, we found that PP2A knock down sensitized cells to several classes of death stimuli (including ER stress), but this effect was abolished in a genetic background featuring knock in of a non-phosphorylatable BCL-2 allele. These studies support the hypothesis that PP2A-mediated dephosphorylation of BCL-2 is required to protect BCL-2 from proteasome-dependent degradation, affecting resistance to ER stress."xsd:string |
| http://purl.uniprot.org/citations/16717086 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m602648200"xsd:string |
| http://purl.uniprot.org/citations/16717086 | http://purl.uniprot.org/core/author | "Lin S.S."xsd:string |
| http://purl.uniprot.org/citations/16717086 | http://purl.uniprot.org/core/author | "Roberts T.M."xsd:string |
| http://purl.uniprot.org/citations/16717086 | http://purl.uniprot.org/core/author | "Nishino M."xsd:string |
| http://purl.uniprot.org/citations/16717086 | http://purl.uniprot.org/core/author | "Bassik M.C."xsd:string |
| http://purl.uniprot.org/citations/16717086 | http://purl.uniprot.org/core/author | "Hahn W.C."xsd:string |
| http://purl.uniprot.org/citations/16717086 | http://purl.uniprot.org/core/author | "Suh H."xsd:string |
| http://purl.uniprot.org/citations/16717086 | http://purl.uniprot.org/core/author | "Korsmeyer S.J."xsd:string |
| http://purl.uniprot.org/citations/16717086 | http://purl.uniprot.org/core/author | "Arroyo J.D."xsd:string |
| http://purl.uniprot.org/citations/16717086 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16717086 | http://purl.uniprot.org/core/name | "J Biol Chem"xsd:string |
| http://purl.uniprot.org/citations/16717086 | http://purl.uniprot.org/core/pages | "23003-23012"xsd:string |
| http://purl.uniprot.org/citations/16717086 | http://purl.uniprot.org/core/title | "PP2A regulates BCL-2 phosphorylation and proteasome-mediated degradation at the endoplasmic reticulum."xsd:string |
| http://purl.uniprot.org/citations/16717086 | http://purl.uniprot.org/core/volume | "281"xsd:string |
| http://purl.uniprot.org/citations/16717086 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/16717086 |
| http://purl.uniprot.org/citations/16717086 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/16717086 |
| http://purl.uniprot.org/uniprot/Q60996#attribution-27792506312C440C35520E70E1896AF4 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/16717086 |
| http://purl.uniprot.org/uniprot/Q13362#attribution-874DECFAD85043EDD3ADCB08D502C03F | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/16717086 |
| http://purl.uniprot.org/uniprot/Q76MZ3#attribution-D916B6F8AB3A72B089891148BD1D4747 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/16717086 |
| http://purl.uniprot.org/uniprot/P10415#attribution-D916B6F8AB3A72B089891148BD1D4747 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/16717086 |
| http://purl.uniprot.org/uniprot/P10417#attribution-27792506312C440C35520E70E1896AF4 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/16717086 |
| http://purl.uniprot.org/uniprot/P10417#attribution-D916B6F8AB3A72B089891148BD1D4747 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/16717086 |
| http://purl.uniprot.org/uniprot/P62715#attribution-874DECFAD85043EDD3ADCB08D502C03F | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/16717086 |