| http://purl.uniprot.org/citations/16723356 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16723356 | http://www.w3.org/2000/01/rdf-schema#comment | "Retinoic acid receptors (RARs) are the molecular relays of retinoid action on transcription, cellular differentiation and apoptosis. Transcriptional activation of retinoid-regulated promoters requires the dismissal of corepressors and the recruitment of coactivators to promoter-bound RAR. RARs recruit in vitro a plethora of coactivators whose actual contribution to retinoid-induced transcription is poorly characterized in vivo. Embryonal carcinoma P19 cells, which are highly sensitive to retinoids, were depleted from archetypical coactivators by RNAi. SRC1-deficient P19 cells showed severely compromised retinoid-induced responses, in agreement with the supposed role of SRC1 as a RAR coactivator. Unexpectedly, Med1/TRAP220/DRIP205-depleted cells exhibited an exacerbated response to retinoids, both in terms transcriptional responses and of cellular differentiation. Med1 depletion affected TFIIH and cdk9 detection at the prototypical retinoid-regulated RARbeta2 promoter, and favored a higher RNA polymerase II detection in transcribed regions of the RARbeta2 gene. Furthermore, the nature of the ligand impacted strongly on the ability of RARs to interact with a given coactivator and to activate transcription in intact cells. Thus RAR accomplishes transcriptional activation as a function of the ligand structure, by recruiting regulatory complexes which control distinct molecular events at retinoid-regulated promoters."xsd:string |
| http://purl.uniprot.org/citations/16723356 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m603023200"xsd:string |
| http://purl.uniprot.org/citations/16723356 | http://purl.uniprot.org/core/author | "Rachez C."xsd:string |
| http://purl.uniprot.org/citations/16723356 | http://purl.uniprot.org/core/author | "Lefebvre B."xsd:string |
| http://purl.uniprot.org/citations/16723356 | http://purl.uniprot.org/core/author | "Lefebvre P."xsd:string |
| http://purl.uniprot.org/citations/16723356 | http://purl.uniprot.org/core/author | "Flajollet S."xsd:string |
| http://purl.uniprot.org/citations/16723356 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16723356 | http://purl.uniprot.org/core/name | "J Biol Chem"xsd:string |
| http://purl.uniprot.org/citations/16723356 | http://purl.uniprot.org/core/pages | "20338-20348"xsd:string |
| http://purl.uniprot.org/citations/16723356 | http://purl.uniprot.org/core/title | "Distinct roles of the steroid receptor coactivator 1 and of MED1 in retinoid-induced transcription and cellular differentiation."xsd:string |
| http://purl.uniprot.org/citations/16723356 | http://purl.uniprot.org/core/volume | "281"xsd:string |
| http://purl.uniprot.org/citations/16723356 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/16723356 |
| http://purl.uniprot.org/citations/16723356 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/16723356 |
| http://purl.uniprot.org/uniprot/Q925J9#attribution-6968588920F850F5FFA0FAE0C0A3053D | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/16723356 |
| http://purl.uniprot.org/uniprot/P70365#attribution-6968588920F850F5FFA0FAE0C0A3053D | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/16723356 |
| http://purl.uniprot.org/uniprot/P22935#attribution-E16F592633722EE592BED4DBB3364245 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/16723356 |
| http://purl.uniprot.org/uniprot/#_A0A0N4SV30-mappedCitation-16723356 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16723356 |
| http://purl.uniprot.org/uniprot/#_A0A0R4J0A8-mappedCitation-16723356 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16723356 |
| http://purl.uniprot.org/uniprot/#_A0A0N4SWA0-mappedCitation-16723356 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16723356 |
| http://purl.uniprot.org/uniprot/#_Q15648-mappedCitation-16723356 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16723356 |
| http://purl.uniprot.org/uniprot/#_A8K1V4-mappedCitation-16723356 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16723356 |
| http://purl.uniprot.org/uniprot/#_A0A1W2P7S6-mappedCitation-16723356 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16723356 |
| http://purl.uniprot.org/uniprot/#_A0A1W2P881-mappedCitation-16723356 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16723356 |
| http://purl.uniprot.org/uniprot/#_A0A1W2P6K7-mappedCitation-16723356 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16723356 |