| http://purl.uniprot.org/citations/16751398 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16751398 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16751398 | http://www.w3.org/2000/01/rdf-schema#comment | "NK1.1 alloantigen expression can be used to define NK cells in certain mouse strains, such as B6 (NKR-P1C) and SJL (NKR-P1B). However, BALB/c NK cells do not react with the anti-NK1.1 mAb, PK136. To investigate the NK1.1(-) phenotype of BALB/c NK cells, we have undertaken NK1.1 epitope mapping and genomic analysis of the BALB/c Nkrp1 region. Bacterial artificial chromosome library analysis reveals that, unlike the Ly49 region, the Nkrp1-Ocil/Clr region displays limited genetic divergence between B6 and BALB/c mice. In fact, significant divergence is confined to the Nkrp1b and Nkrp1c genes. Strikingly, the B6 Nkrp1d gene appears to represent a divergent allele of the Nkrp1b gene in BALB/c mice and other strains. Importantly, BALB/c NK cells express abundant and functional Nkrp1 transcripts, and the BALB/c NKR-P1B receptor functionally binds Ocil/Clr-b ligand. However, the BALB/c NKR-P1B/C sequences differ from those of the known NK1.1 alloantigens, and epitope mapping demonstrates that directed mutation of a single amino acid in the NKR-P1B(BALB) protein confers NK1.1 reactivity. Thus, PK136 mAb recognizes, in part, a distal C-terminal epitope present in NKR-P1B(Sw/SJL) and NKR-P1C(B6), but absent in NKR-P1A/D/F(B6) and NKR-P1B/C(BALB). Allelic divergence of the Nkrp1b/c gene products and limited divergence of the BALB/c Nkrp1-Ocil/Clr region explain a longstanding confusion regarding the strain-specific NK1.1 alloantigen reactivity of mouse NK cells."xsd:string |
| http://purl.uniprot.org/citations/16751398 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.176.12.7511"xsd:string |
| http://purl.uniprot.org/citations/16751398 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.176.12.7511"xsd:string |
| http://purl.uniprot.org/citations/16751398 | http://purl.uniprot.org/core/author | "Belanger S."xsd:string |
| http://purl.uniprot.org/citations/16751398 | http://purl.uniprot.org/core/author | "Belanger S."xsd:string |
| http://purl.uniprot.org/citations/16751398 | http://purl.uniprot.org/core/author | "Carlyle J.R."xsd:string |
| http://purl.uniprot.org/citations/16751398 | http://purl.uniprot.org/core/author | "Carlyle J.R."xsd:string |
| http://purl.uniprot.org/citations/16751398 | http://purl.uniprot.org/core/author | "Ljutic B."xsd:string |
| http://purl.uniprot.org/citations/16751398 | http://purl.uniprot.org/core/author | "Ljutic B."xsd:string |
| http://purl.uniprot.org/citations/16751398 | http://purl.uniprot.org/core/author | "Makrigiannis A.P."xsd:string |
| http://purl.uniprot.org/citations/16751398 | http://purl.uniprot.org/core/author | "Makrigiannis A.P."xsd:string |
| http://purl.uniprot.org/citations/16751398 | http://purl.uniprot.org/core/author | "Mesci A."xsd:string |
| http://purl.uniprot.org/citations/16751398 | http://purl.uniprot.org/core/author | "Mesci A."xsd:string |
| http://purl.uniprot.org/citations/16751398 | http://purl.uniprot.org/core/author | "Proteau M.-F."xsd:string |
| http://purl.uniprot.org/citations/16751398 | http://purl.uniprot.org/core/author | "Proteau M.-F."xsd:string |
| http://purl.uniprot.org/citations/16751398 | http://purl.uniprot.org/core/author | "Rousselle E."xsd:string |
| http://purl.uniprot.org/citations/16751398 | http://purl.uniprot.org/core/author | "Rousselle E."xsd:string |
| http://purl.uniprot.org/citations/16751398 | http://purl.uniprot.org/core/author | "Tai L.-H."xsd:string |
| http://purl.uniprot.org/citations/16751398 | http://purl.uniprot.org/core/author | "Tai L.-H."xsd:string |
| http://purl.uniprot.org/citations/16751398 | http://purl.uniprot.org/core/author | "Troke A.D."xsd:string |
| http://purl.uniprot.org/citations/16751398 | http://purl.uniprot.org/core/author | "Troke A.D."xsd:string |
| http://purl.uniprot.org/citations/16751398 | http://purl.uniprot.org/core/author | "Proteau M.F."xsd:string |
| http://purl.uniprot.org/citations/16751398 | http://purl.uniprot.org/core/author | "Tai L.H."xsd:string |