| http://purl.uniprot.org/citations/16775013 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16775013 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16775013 | http://www.w3.org/2000/01/rdf-schema#comment | "Rab11a, myosin Vb, and the Rab11-family interacting protein 2 (FIP2) regulate plasma membrane recycling in epithelial cells. This study sought to characterize more fully Rab11-FIP2 function by identifying kinase activities modifying Rab11-FIP2. We have found that gastric microsomal membrane extracts phosphorylate Rab11-FIP2 on serine 227. We identified the kinase that phosphorylated Rab11-FIP2 as MARK2/EMK1/Par-1Balpha (MARK2), and recombinant MARK2 phosphorylated Rab11-FIP2 only on serine 227. We created stable Madin-Darby canine kidney (MDCK) cell lines expressing enhanced green fluorescent protein-Rab11-FIP2 wild type or a nonphosphorylatable mutant [Rab11-FIP2(S227A)]. Analysis of these cell lines demonstrates a new role for Rab11-FIP2 in addition to that in the plasma membrane recycling system. In calcium switch assays, cells expressing Rab11-FIP2(S227A) showed a defect in the timely reestablishment of p120-containing junctional complexes. However, Rab11-FIP2(S227A) did not affect localization with recycling system components or the normal function of apical recycling and transcytosis pathways. These results indicate that phosphorylation of Rab11-FIP2 on serine 227 by MARK2 regulates an alternative pathway modulating the establishment of epithelial polarity."xsd:string |
| http://purl.uniprot.org/citations/16775013 | http://purl.org/dc/terms/identifier | "doi:10.1091/mbc.e05-08-0736"xsd:string |
| http://purl.uniprot.org/citations/16775013 | http://purl.org/dc/terms/identifier | "doi:10.1091/mbc.e05-08-0736"xsd:string |
| http://purl.uniprot.org/citations/16775013 | http://purl.uniprot.org/core/author | "Goldenring J.R."xsd:string |
| http://purl.uniprot.org/citations/16775013 | http://purl.uniprot.org/core/author | "Goldenring J.R."xsd:string |
| http://purl.uniprot.org/citations/16775013 | http://purl.uniprot.org/core/author | "Ham A.J."xsd:string |
| http://purl.uniprot.org/citations/16775013 | http://purl.uniprot.org/core/author | "Ham A.J."xsd:string |
| http://purl.uniprot.org/citations/16775013 | http://purl.uniprot.org/core/author | "Apodaca G."xsd:string |
| http://purl.uniprot.org/citations/16775013 | http://purl.uniprot.org/core/author | "Apodaca G."xsd:string |
| http://purl.uniprot.org/citations/16775013 | http://purl.uniprot.org/core/author | "Ducharme N.A."xsd:string |
| http://purl.uniprot.org/citations/16775013 | http://purl.uniprot.org/core/author | "Ducharme N.A."xsd:string |
| http://purl.uniprot.org/citations/16775013 | http://purl.uniprot.org/core/author | "Hales C.M."xsd:string |
| http://purl.uniprot.org/citations/16775013 | http://purl.uniprot.org/core/author | "Hales C.M."xsd:string |
| http://purl.uniprot.org/citations/16775013 | http://purl.uniprot.org/core/author | "Lapierre L.A."xsd:string |
| http://purl.uniprot.org/citations/16775013 | http://purl.uniprot.org/core/author | "Lapierre L.A."xsd:string |
| http://purl.uniprot.org/citations/16775013 | http://purl.uniprot.org/core/author | "Oztan A."xsd:string |
| http://purl.uniprot.org/citations/16775013 | http://purl.uniprot.org/core/author | "Oztan A."xsd:string |
| http://purl.uniprot.org/citations/16775013 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16775013 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16775013 | http://purl.uniprot.org/core/name | "Mol. Biol. Cell"xsd:string |
| http://purl.uniprot.org/citations/16775013 | http://purl.uniprot.org/core/name | "Mol. Biol. Cell"xsd:string |
| http://purl.uniprot.org/citations/16775013 | http://purl.uniprot.org/core/pages | "3625-3637"xsd:string |
| http://purl.uniprot.org/citations/16775013 | http://purl.uniprot.org/core/pages | "3625-3637"xsd:string |