| http://purl.uniprot.org/citations/16815842 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16815842 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16815842 | http://www.w3.org/2000/01/rdf-schema#comment | "ErbB-4 is cleaved by alpha- and gamma-secretases to release a soluble 80-kDa intracellular domain, termed s80, which translocates to the nucleus. s80 is present in the nucleus of normal and cancerous mammary cells and is predicted to have a role in cell differentiation. To further investigate the mechanism by which s80 may mediate differentiation, we tested whether s80 regulates Eto2, a transcriptional corepressor that is involved in erythrocyte differentiation and is also implicated in human breast cancer. Here we show that ligand binding to ErbB-4 causes s80 translocation to the nucleus, where it colocalizes and interacts with Eto2. Expression of s80 blocks Eto2-mediated transcriptional repression of a heterologous promoter. This effect on Eto2 does not require s80 kinase activity and is mediated by the carboxyl-terminal region of s80. Although other cell surface receptors regulate transcription by activating signal transduction cascades, these data present a novel mechanism of corepressor regulation and suggest a role for Eto2 in ErbB-4-dependent differentiation."xsd:string |
| http://purl.uniprot.org/citations/16815842 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m603998200"xsd:string |
| http://purl.uniprot.org/citations/16815842 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m603998200"xsd:string |
| http://purl.uniprot.org/citations/16815842 | http://purl.uniprot.org/core/author | "Carpenter G."xsd:string |
| http://purl.uniprot.org/citations/16815842 | http://purl.uniprot.org/core/author | "Carpenter G."xsd:string |
| http://purl.uniprot.org/citations/16815842 | http://purl.uniprot.org/core/author | "Linggi B."xsd:string |
| http://purl.uniprot.org/citations/16815842 | http://purl.uniprot.org/core/author | "Linggi B."xsd:string |
| http://purl.uniprot.org/citations/16815842 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16815842 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16815842 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/16815842 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/16815842 | http://purl.uniprot.org/core/pages | "25373-25380"xsd:string |
| http://purl.uniprot.org/citations/16815842 | http://purl.uniprot.org/core/pages | "25373-25380"xsd:string |
| http://purl.uniprot.org/citations/16815842 | http://purl.uniprot.org/core/title | "ErbB-4 s80 intracellular domain abrogates ETO2-dependent transcriptional repression."xsd:string |
| http://purl.uniprot.org/citations/16815842 | http://purl.uniprot.org/core/title | "ErbB-4 s80 intracellular domain abrogates ETO2-dependent transcriptional repression."xsd:string |
| http://purl.uniprot.org/citations/16815842 | http://purl.uniprot.org/core/volume | "281"xsd:string |
| http://purl.uniprot.org/citations/16815842 | http://purl.uniprot.org/core/volume | "281"xsd:string |
| http://purl.uniprot.org/citations/16815842 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/16815842 |
| http://purl.uniprot.org/citations/16815842 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/16815842 |
| http://purl.uniprot.org/citations/16815842 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/16815842 |
| http://purl.uniprot.org/citations/16815842 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/16815842 |
| http://purl.uniprot.org/uniprot/Q61527 | http://purl.uniprot.org/core/citation | http://purl.uniprot.org/citations/16815842 |
| http://purl.uniprot.org/uniprot/O75081 | http://purl.uniprot.org/core/citation | http://purl.uniprot.org/citations/16815842 |