| http://purl.uniprot.org/citations/16818604 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16818604 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16818604 | http://www.w3.org/2000/01/rdf-schema#comment | "BRCA1 (Breast Cancer Susceptibility Gene 1) possesses an N-terminal Ring domain and tandem C-terminal BRCT motifs. While the Ring domain has E3 ubiquitin ligase activity, the BRCA1 BRCT domains specifically recognize phospho-serine motifs. Here, we demonstrate that BRCA1 Ring domain catalyzes CtIP ubiquitination in a manner that depends on a phosphorylation-mediated interaction between CtIP and BRCA1 BRCT domains. The BRCA1-dependent ubiquitination of CtIP does not target CtIP for degradation. Instead, ubiquitinated CtIP associates with chromatin following DNA damage and participates in G2/M checkpoint control. Thus, we propose that BRCA1 can regulate the functions of its substrates through nonproteasomal pathways that do not involve substrate degradation."xsd:string |
| http://purl.uniprot.org/citations/16818604 | http://purl.org/dc/terms/identifier | "doi:10.1101/gad.1431006"xsd:string |
| http://purl.uniprot.org/citations/16818604 | http://purl.org/dc/terms/identifier | "doi:10.1101/gad.1431006"xsd:string |
| http://purl.uniprot.org/citations/16818604 | http://purl.uniprot.org/core/author | "Chen J."xsd:string |
| http://purl.uniprot.org/citations/16818604 | http://purl.uniprot.org/core/author | "Chen J."xsd:string |
| http://purl.uniprot.org/citations/16818604 | http://purl.uniprot.org/core/author | "Baer R."xsd:string |
| http://purl.uniprot.org/citations/16818604 | http://purl.uniprot.org/core/author | "Baer R."xsd:string |
| http://purl.uniprot.org/citations/16818604 | http://purl.uniprot.org/core/author | "Fu S."xsd:string |
| http://purl.uniprot.org/citations/16818604 | http://purl.uniprot.org/core/author | "Fu S."xsd:string |
| http://purl.uniprot.org/citations/16818604 | http://purl.uniprot.org/core/author | "Yu X."xsd:string |
| http://purl.uniprot.org/citations/16818604 | http://purl.uniprot.org/core/author | "Yu X."xsd:string |
| http://purl.uniprot.org/citations/16818604 | http://purl.uniprot.org/core/author | "Lai M."xsd:string |
| http://purl.uniprot.org/citations/16818604 | http://purl.uniprot.org/core/author | "Lai M."xsd:string |
| http://purl.uniprot.org/citations/16818604 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16818604 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16818604 | http://purl.uniprot.org/core/name | "Genes Dev."xsd:string |
| http://purl.uniprot.org/citations/16818604 | http://purl.uniprot.org/core/name | "Genes Dev."xsd:string |
| http://purl.uniprot.org/citations/16818604 | http://purl.uniprot.org/core/pages | "1721-1726"xsd:string |
| http://purl.uniprot.org/citations/16818604 | http://purl.uniprot.org/core/pages | "1721-1726"xsd:string |
| http://purl.uniprot.org/citations/16818604 | http://purl.uniprot.org/core/title | "BRCA1 ubiquitinates its phosphorylation-dependent binding partner CtIP."xsd:string |
| http://purl.uniprot.org/citations/16818604 | http://purl.uniprot.org/core/title | "BRCA1 ubiquitinates its phosphorylation-dependent binding partner CtIP."xsd:string |
| http://purl.uniprot.org/citations/16818604 | http://purl.uniprot.org/core/volume | "20"xsd:string |
| http://purl.uniprot.org/citations/16818604 | http://purl.uniprot.org/core/volume | "20"xsd:string |