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| http://purl.uniprot.org/citations/16828735 | http://www.w3.org/2000/01/rdf-schema#comment | "Boundaries establish and maintain separate populations of cells critical for organ formation. We show that Notch signaling establishes the boundary between two types of post-mitotic epithelial cells, the Rhomboid- and the Broad-positive cells. These cells will undergo morphogenetic movements to generate the two sides of a simple organ, the dorsal appendage tube of the Drosophila egg chamber. The boundary forms due to a difference in Notch levels in adjacent cells. The Notch expression pattern mimics the boundary; Notch levels are high in Rhomboid cells and low in Broad cells. Notch(-) mutant clones generate an ectopic boundary: ectopic Rhomboid cells arise in Notch(+) cells adjacent to the Notch(-) mutant cells but not further away from the clonal border. Pangolin, a component of the Wingless pathway, is required for Broad expression and for rhomboid repression. We further show that Broad represses rhomboid cell autonomously. Our data provide a foundation for understanding how a single row of Rhomboid cells arises adjacent to the Broad cells in the dorsal appendage primordia. Generating a boundary by the Notch pathway might constitute an evolutionarily conserved first step during organ formation in many tissues."xsd:string |
| http://purl.uniprot.org/citations/16828735 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.ydbio.2006.05.021"xsd:string |
| http://purl.uniprot.org/citations/16828735 | http://purl.uniprot.org/core/author | "Zhou X."xsd:string |
| http://purl.uniprot.org/citations/16828735 | http://purl.uniprot.org/core/author | "Riddiford L.M."xsd:string |
| http://purl.uniprot.org/citations/16828735 | http://purl.uniprot.org/core/author | "Berg C.A."xsd:string |
| http://purl.uniprot.org/citations/16828735 | http://purl.uniprot.org/core/author | "Ruohola-Baker H."xsd:string |
| http://purl.uniprot.org/citations/16828735 | http://purl.uniprot.org/core/author | "Ward E.J."xsd:string |
| http://purl.uniprot.org/citations/16828735 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16828735 | http://purl.uniprot.org/core/name | "Dev Biol"xsd:string |
| http://purl.uniprot.org/citations/16828735 | http://purl.uniprot.org/core/pages | "461-470"xsd:string |
| http://purl.uniprot.org/citations/16828735 | http://purl.uniprot.org/core/title | "Border of Notch activity establishes a boundary between the two dorsal appendage tube cell types."xsd:string |
| http://purl.uniprot.org/citations/16828735 | http://purl.uniprot.org/core/volume | "297"xsd:string |
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