| http://purl.uniprot.org/citations/16862143 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16862143 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16862143 | http://www.w3.org/2000/01/rdf-schema#comment | "The cellular DNA-damage response is a signaling network that is vigorously activated by cytotoxic DNA lesions, such as double-strand breaks (DSBs). The DSB response is mobilized by the nuclear protein kinase ATM, which modulates this process by phosphorylating key players in these pathways. A long-standing question in this field is whether DSB formation affects chromatin condensation. Here, we show that DSB formation is followed by ATM-dependent chromatin relaxation. ATM's effector in this pathway is the protein KRAB-associated protein (KAP-1, also known as TIF1beta, KRIP-1 or TRIM28), previously known as a corepressor of gene transcription. In response to DSB induction, KAP-1 is phosphorylated in an ATM-dependent manner on Ser 824. KAP-1 is phosphorylated exclusively at the damage sites, from which phosphorylated KAP-1 spreads rapidly throughout the chromatin. Ablation of the phosphorylation site of KAP-1 leads to loss of DSB-induced chromatin decondensation and renders the cells hypersensitive to DSB-inducing agents. Knocking down KAP-1, or mimicking a constitutive phosphorylation of this protein, leads to constitutive chromatin relaxation. These results suggest that chromatin relaxation is a fundamental pathway in the DNA-damage response and identify its primary mediators."xsd:string |
| http://purl.uniprot.org/citations/16862143 | http://purl.org/dc/terms/identifier | "doi:10.1038/ncb1446"xsd:string |
| http://purl.uniprot.org/citations/16862143 | http://purl.org/dc/terms/identifier | "doi:10.1038/ncb1446"xsd:string |
| http://purl.uniprot.org/citations/16862143 | http://purl.uniprot.org/core/author | "Shiloh Y."xsd:string |
| http://purl.uniprot.org/citations/16862143 | http://purl.uniprot.org/core/author | "Shiloh Y."xsd:string |
| http://purl.uniprot.org/citations/16862143 | http://purl.uniprot.org/core/author | "Taya Y."xsd:string |
| http://purl.uniprot.org/citations/16862143 | http://purl.uniprot.org/core/author | "Taya Y."xsd:string |
| http://purl.uniprot.org/citations/16862143 | http://purl.uniprot.org/core/author | "Lukas C."xsd:string |
| http://purl.uniprot.org/citations/16862143 | http://purl.uniprot.org/core/author | "Lukas C."xsd:string |
| http://purl.uniprot.org/citations/16862143 | http://purl.uniprot.org/core/author | "Lukas J."xsd:string |
| http://purl.uniprot.org/citations/16862143 | http://purl.uniprot.org/core/author | "Lukas J."xsd:string |
| http://purl.uniprot.org/citations/16862143 | http://purl.uniprot.org/core/author | "Bartek J."xsd:string |
| http://purl.uniprot.org/citations/16862143 | http://purl.uniprot.org/core/author | "Bartek J."xsd:string |
| http://purl.uniprot.org/citations/16862143 | http://purl.uniprot.org/core/author | "Schultz D.C."xsd:string |
| http://purl.uniprot.org/citations/16862143 | http://purl.uniprot.org/core/author | "Schultz D.C."xsd:string |
| http://purl.uniprot.org/citations/16862143 | http://purl.uniprot.org/core/author | "Bekker-Jensen S."xsd:string |
| http://purl.uniprot.org/citations/16862143 | http://purl.uniprot.org/core/author | "Bekker-Jensen S."xsd:string |
| http://purl.uniprot.org/citations/16862143 | http://purl.uniprot.org/core/author | "Galanty Y."xsd:string |
| http://purl.uniprot.org/citations/16862143 | http://purl.uniprot.org/core/author | "Galanty Y."xsd:string |
| http://purl.uniprot.org/citations/16862143 | http://purl.uniprot.org/core/author | "Ziv Y."xsd:string |
| http://purl.uniprot.org/citations/16862143 | http://purl.uniprot.org/core/author | "Ziv Y."xsd:string |
| http://purl.uniprot.org/citations/16862143 | http://purl.uniprot.org/core/author | "Bielopolski D."xsd:string |
| http://purl.uniprot.org/citations/16862143 | http://purl.uniprot.org/core/author | "Bielopolski D."xsd:string |