| http://purl.uniprot.org/citations/16892051 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16892051 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16892051 | http://www.w3.org/2000/01/rdf-schema#comment | "The nicotinamide adenine dinucleotide (NAD)-dependent deacetylase Sir2 (silent information regulator 2) regulates gene silencing in yeast and promotes lifespan extension during caloric restriction. The mammalian homologue of Sir2 (SirT1) regulates p53, NF-kappaB and Forkhead transcription factors, and is implicated in stress response. This report shows that the cell-cycle and apoptosis regulator E2F1 induces SirT1 expression at the transcriptional level. Furthermore, SirT1 binds to E2F1 and inhibits E2F1 activities, forming a negative feedback loop. Knockdown of SirT1 by small interference RNA (siRNA) increases E2F1 transcriptional and apoptotic functions. DNA damage by etoposide causes E2F1-dependent induction of SirT1 expression and knockdown of SirT1 increases sensitivity to etoposide. These results reveal a mutual regulation between E2F1 and SirT1 that affects cellular sensitivity to DNA damage."xsd:string |
| http://purl.uniprot.org/citations/16892051 | http://purl.org/dc/terms/identifier | "doi:10.1038/ncb1468"xsd:string |
| http://purl.uniprot.org/citations/16892051 | http://purl.org/dc/terms/identifier | "doi:10.1038/ncb1468"xsd:string |
| http://purl.uniprot.org/citations/16892051 | http://purl.uniprot.org/core/author | "Chen J."xsd:string |
| http://purl.uniprot.org/citations/16892051 | http://purl.uniprot.org/core/author | "Chen J."xsd:string |
| http://purl.uniprot.org/citations/16892051 | http://purl.uniprot.org/core/author | "Chen L."xsd:string |
| http://purl.uniprot.org/citations/16892051 | http://purl.uniprot.org/core/author | "Chen L."xsd:string |
| http://purl.uniprot.org/citations/16892051 | http://purl.uniprot.org/core/author | "Gu W."xsd:string |
| http://purl.uniprot.org/citations/16892051 | http://purl.uniprot.org/core/author | "Gu W."xsd:string |
| http://purl.uniprot.org/citations/16892051 | http://purl.uniprot.org/core/author | "Li Z."xsd:string |
| http://purl.uniprot.org/citations/16892051 | http://purl.uniprot.org/core/author | "Li Z."xsd:string |
| http://purl.uniprot.org/citations/16892051 | http://purl.uniprot.org/core/author | "Ma Y."xsd:string |
| http://purl.uniprot.org/citations/16892051 | http://purl.uniprot.org/core/author | "Ma Y."xsd:string |
| http://purl.uniprot.org/citations/16892051 | http://purl.uniprot.org/core/author | "Wang C."xsd:string |
| http://purl.uniprot.org/citations/16892051 | http://purl.uniprot.org/core/author | "Wang C."xsd:string |
| http://purl.uniprot.org/citations/16892051 | http://purl.uniprot.org/core/author | "Hou X."xsd:string |
| http://purl.uniprot.org/citations/16892051 | http://purl.uniprot.org/core/author | "Hou X."xsd:string |
| http://purl.uniprot.org/citations/16892051 | http://purl.uniprot.org/core/author | "Finkel T."xsd:string |
| http://purl.uniprot.org/citations/16892051 | http://purl.uniprot.org/core/author | "Finkel T."xsd:string |
| http://purl.uniprot.org/citations/16892051 | http://purl.uniprot.org/core/author | "Kabra N."xsd:string |
| http://purl.uniprot.org/citations/16892051 | http://purl.uniprot.org/core/author | "Kabra N."xsd:string |
| http://purl.uniprot.org/citations/16892051 | http://purl.uniprot.org/core/author | "Cress W.D."xsd:string |
| http://purl.uniprot.org/citations/16892051 | http://purl.uniprot.org/core/author | "Cress W.D."xsd:string |