| http://purl.uniprot.org/citations/16945374 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16945374 | http://www.w3.org/2000/01/rdf-schema#comment | "Apolipoprotein A-IV (apoA-IV) inhibits lipid peroxidation, thus demonstrating potential anti-atherogenic properties. The aim of this study was to investigate how the inhibition of low density lipoprotein (LDL) oxidation was influenced by common apoA-IV isoforms. Recombinant wild type apoA-IV (100 microg/ml) significantly inhibited the oxidation of LDL (50 microg protein/ml) by 5 microM CuSO(4) (P<0.005), but not by 100 microM CuSO(4), suggesting that it may act by binding copper ions. ApoA-IV also inhibited the oxidation of LDL by the water-soluble free-radical generator 2,2'-azobis(amidinopropane) dihydrochloride (AAPH; 1 mM), as shown by the two-fold increase in the time for half maximal conjugated diene formation (T(1/2); P<0.05) suggesting it can also scavenge free radicals in the aqueous phase. Compared to wild type apoA-IV, apoA-IV-S347 decreased T(1/2) by 15% (P=0.036) and apoA-IV-H360 increased T(1/2) by 18% (P=0.046). All apoA-IV isoforms increased the relative electrophoretic mobility of native LDL, suggesting apoA-IV can bind to LDL and acts as a site-specific antioxidant. The reduced inhibition of LDL oxidation by apoA-IV-S347 compared to wild type apoA-IV may account for the previous association of the APOA4 S347 variant with increased CHD risk and oxidative stress."xsd:string |
| http://purl.uniprot.org/citations/16945374 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.atherosclerosis.2006.07.017"xsd:string |
| http://purl.uniprot.org/citations/16945374 | http://purl.uniprot.org/core/author | "Wong W.M."xsd:string |
| http://purl.uniprot.org/citations/16945374 | http://purl.uniprot.org/core/author | "Humphries S.E."xsd:string |
| http://purl.uniprot.org/citations/16945374 | http://purl.uniprot.org/core/author | "Weinberg R.B."xsd:string |
| http://purl.uniprot.org/citations/16945374 | http://purl.uniprot.org/core/author | "Talmud P.J."xsd:string |
| http://purl.uniprot.org/citations/16945374 | http://purl.uniprot.org/core/author | "Putt W."xsd:string |
| http://purl.uniprot.org/citations/16945374 | http://purl.uniprot.org/core/author | "Roberts J.L."xsd:string |
| http://purl.uniprot.org/citations/16945374 | http://purl.uniprot.org/core/author | "Leake D.S."xsd:string |
| http://purl.uniprot.org/citations/16945374 | http://purl.uniprot.org/core/author | "Gerry A.B."xsd:string |
| http://purl.uniprot.org/citations/16945374 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/16945374 | http://purl.uniprot.org/core/name | "Atherosclerosis"xsd:string |
| http://purl.uniprot.org/citations/16945374 | http://purl.uniprot.org/core/pages | "266-274"xsd:string |
| http://purl.uniprot.org/citations/16945374 | http://purl.uniprot.org/core/title | "Common variants of apolipoprotein A-IV differ in their ability to inhibit low density lipoprotein oxidation."xsd:string |
| http://purl.uniprot.org/citations/16945374 | http://purl.uniprot.org/core/volume | "192"xsd:string |
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| http://purl.uniprot.org/citations/16945374 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/16945374 |
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