| http://purl.uniprot.org/citations/16951545 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16951545 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16951545 | http://www.w3.org/2000/01/rdf-schema#comment | "Hepatitis C virus (HCV) non-structural protein 5A protein (NS5A), which consists of three functional domains, is involved in regulating viral replication, interferon resistance, and apoptosis. Recently, the three-dimensional structure of the domain 1 was determined. However, currently the molecular basis for the domains 2 and 3 of HCV NS5A is yet to be defined. Toward this end, we expressed, purified the domain 2 of the NS5A (NS5A-D2), and then performed biochemical and structural studies. The purified domain 2 was active and was able to bind NS5B and PKR, biological partners of NS5A. The results from gel filtration, CD analysis, 1D 1H NMR and 2D 1H-15N heteronuclear single quantum correlation (HSQC) spectroscopy indicate that the domain 2 of NS5A appears to be flexible and disordered."xsd:string |
| http://purl.uniprot.org/citations/16951545 | http://purl.uniprot.org/core/author | "Liang Y."xsd:string |
| http://purl.uniprot.org/citations/16951545 | http://purl.uniprot.org/core/author | "Liang Y."xsd:string |
| http://purl.uniprot.org/citations/16951545 | http://purl.uniprot.org/core/author | "Kang C.B."xsd:string |
| http://purl.uniprot.org/citations/16951545 | http://purl.uniprot.org/core/author | "Kang C.B."xsd:string |
| http://purl.uniprot.org/citations/16951545 | http://purl.uniprot.org/core/author | "Yoon H.S."xsd:string |
| http://purl.uniprot.org/citations/16951545 | http://purl.uniprot.org/core/author | "Yoon H.S."xsd:string |
| http://purl.uniprot.org/citations/16951545 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16951545 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16951545 | http://purl.uniprot.org/core/name | "Mol. Cells"xsd:string |
| http://purl.uniprot.org/citations/16951545 | http://purl.uniprot.org/core/name | "Mol. Cells"xsd:string |
| http://purl.uniprot.org/citations/16951545 | http://purl.uniprot.org/core/pages | "13-20"xsd:string |
| http://purl.uniprot.org/citations/16951545 | http://purl.uniprot.org/core/pages | "13-20"xsd:string |
| http://purl.uniprot.org/citations/16951545 | http://purl.uniprot.org/core/title | "Molecular and structural characterization of the domain 2 of hepatitis C virus non-structural protein 5A."xsd:string |
| http://purl.uniprot.org/citations/16951545 | http://purl.uniprot.org/core/title | "Molecular and structural characterization of the domain 2 of hepatitis C virus non-structural protein 5A."xsd:string |
| http://purl.uniprot.org/citations/16951545 | http://purl.uniprot.org/core/volume | "22"xsd:string |
| http://purl.uniprot.org/citations/16951545 | http://purl.uniprot.org/core/volume | "22"xsd:string |
| http://purl.uniprot.org/citations/16951545 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/16951545 |
| http://purl.uniprot.org/citations/16951545 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/16951545 |
| http://purl.uniprot.org/citations/16951545 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/16951545 |
| http://purl.uniprot.org/citations/16951545 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/16951545 |
| http://purl.uniprot.org/uniprot/P27958 | http://purl.uniprot.org/core/citation | http://purl.uniprot.org/citations/16951545 |
| http://purl.uniprot.org/uniprot/P19525 | http://purl.uniprot.org/core/citation | http://purl.uniprot.org/citations/16951545 |