| http://purl.uniprot.org/citations/16952051 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16952051 | http://www.w3.org/2000/01/rdf-schema#comment | "Methionine and metabolites such as S-adenosylmethionine (AdoMet) are of vital importance for eukaryotes; AdoMet is the main donor of methyl groups and is involved in expression control of the methionine biosynthesis genes (MET genes). Genome-wide expression profiling of protein kinase CK2 deletion strains of the budding yeast Saccharomyces cerevisiae has indicated a function for CK2 in MET gene control. Deletion of the regulatory CK2 subunits leads to MET gene repression, presumably due to an impaired phosphorylation of the ubiquitin-conjugating enzyme Cdc34, which controls the central MET gene transcription factor Met4. We show that CK2 phosphorylates Cdc34 at two sites and one of these, Ser282, has a significant impact on MET gene expression in vivo, and that high AdoMet levels inhibit CK2. The data provide evidence for a control of MET gene expression by protein kinase CK2-mediated phosphorylation of Cdc34, and appear to suggest a feedback control loop in which high AdoMet-levels are limiting CK2 activity and thus MET gene expression."xsd:string |
| http://purl.uniprot.org/citations/16952051 | http://purl.org/dc/terms/identifier | "doi:10.1007/s00018-006-6213-5"xsd:string |
| http://purl.uniprot.org/citations/16952051 | http://purl.uniprot.org/core/author | "Ackermann K."xsd:string |
| http://purl.uniprot.org/citations/16952051 | http://purl.uniprot.org/core/author | "Pyerin W."xsd:string |
| http://purl.uniprot.org/citations/16952051 | http://purl.uniprot.org/core/author | "Barz T."xsd:string |
| http://purl.uniprot.org/citations/16952051 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16952051 | http://purl.uniprot.org/core/name | "Cell Mol Life Sci"xsd:string |
| http://purl.uniprot.org/citations/16952051 | http://purl.uniprot.org/core/pages | "2183-2190"xsd:string |
| http://purl.uniprot.org/citations/16952051 | http://purl.uniprot.org/core/title | "Control of methionine biosynthesis genes by protein kinase CK2-mediated phosphorylation of Cdc34."xsd:string |
| http://purl.uniprot.org/citations/16952051 | http://purl.uniprot.org/core/volume | "63"xsd:string |
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