| http://purl.uniprot.org/citations/16959567 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16959567 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16959567 | http://www.w3.org/2000/01/rdf-schema#comment | "Yersinia spp. cause gastroenteritis and the plague, representing historically devastating pathogens that are currently an important biodefense and antibiotic resistance concern. A critical virulence determinant is the Yersinia protein kinase A, or YpkA, a multidomain protein that disrupts the eukaryotic actin cytoskeleton. Here we solve the crystal structure of a YpkA-Rac1 complex and find that YpkA possesses a Rac1 binding domain that mimics host guanidine nucleotide dissociation inhibitors (GDIs) of the Rho GTPases. YpkA inhibits nucleotide exchange in Rac1 and RhoA, and mutations that disrupt the YpkA-GTPase interface abolish this activity in vitro and impair in vivo YpkA-induced cytoskeletal disruption. In cell culture experiments, the kinase and the GDI domains of YpkA act synergistically to promote cytoskeletal disruption, and a Y. pseudotuberculosis mutant lacking YpkA GDI activity shows attenuated virulence in a mouse infection assay. We conclude that virulence in Yersinia depends strongly upon mimicry of host GDI proteins by YpkA."xsd:string |
| http://purl.uniprot.org/citations/16959567 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.cell.2006.06.056"xsd:string |
| http://purl.uniprot.org/citations/16959567 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.cell.2006.06.056"xsd:string |
| http://purl.uniprot.org/citations/16959567 | http://purl.uniprot.org/core/author | "Bliska J.B."xsd:string |
| http://purl.uniprot.org/citations/16959567 | http://purl.uniprot.org/core/author | "Bliska J.B."xsd:string |
| http://purl.uniprot.org/citations/16959567 | http://purl.uniprot.org/core/author | "Stebbins C.E."xsd:string |
| http://purl.uniprot.org/citations/16959567 | http://purl.uniprot.org/core/author | "Stebbins C.E."xsd:string |
| http://purl.uniprot.org/citations/16959567 | http://purl.uniprot.org/core/author | "Prehna G."xsd:string |
| http://purl.uniprot.org/citations/16959567 | http://purl.uniprot.org/core/author | "Prehna G."xsd:string |
| http://purl.uniprot.org/citations/16959567 | http://purl.uniprot.org/core/author | "Ivanov M.I."xsd:string |
| http://purl.uniprot.org/citations/16959567 | http://purl.uniprot.org/core/author | "Ivanov M.I."xsd:string |
| http://purl.uniprot.org/citations/16959567 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16959567 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16959567 | http://purl.uniprot.org/core/name | "Cell"xsd:string |
| http://purl.uniprot.org/citations/16959567 | http://purl.uniprot.org/core/name | "Cell"xsd:string |
| http://purl.uniprot.org/citations/16959567 | http://purl.uniprot.org/core/pages | "869-880"xsd:string |
| http://purl.uniprot.org/citations/16959567 | http://purl.uniprot.org/core/pages | "869-880"xsd:string |
| http://purl.uniprot.org/citations/16959567 | http://purl.uniprot.org/core/title | "Yersinia virulence depends on mimicry of host Rho-family nucleotide dissociation inhibitors."xsd:string |
| http://purl.uniprot.org/citations/16959567 | http://purl.uniprot.org/core/title | "Yersinia virulence depends on mimicry of host Rho-family nucleotide dissociation inhibitors."xsd:string |
| http://purl.uniprot.org/citations/16959567 | http://purl.uniprot.org/core/volume | "126"xsd:string |
| http://purl.uniprot.org/citations/16959567 | http://purl.uniprot.org/core/volume | "126"xsd:string |
| http://purl.uniprot.org/citations/16959567 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/16959567 |
| http://purl.uniprot.org/citations/16959567 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/16959567 |