| http://purl.uniprot.org/citations/16980616 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16980616 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16980616 | http://www.w3.org/2000/01/rdf-schema#comment | "Adhesion of T cells after stimulation of the T-cell receptor (TCR) is mediated via signaling processes that have collectively been termed inside-out signaling. The molecular basis for inside-out signaling is not yet completely understood. Here, we show that a signaling module comprising the cytosolic adapter proteins ADAP and SKAP55 is involved in TCR-mediated inside-out signaling and, moreover, that the interaction between ADAP and SKAP55 is mandatory for integrin activation. Disruption of the ADAP/SKAP55 module leads to displacement of the small GTPase Rap1 from the plasma membrane without influencing its GTPase activity. These findings suggest that the ADAP/SKAP55 complex serves to recruit activated Rap1 to the plasma membrane. In line with this hypothesis is the finding that membrane targeting of the ADAP/SKAP55 module induces T-cell adhesion in the absence of TCR-mediated stimuli. However, it appears as if the ADAP/SKAP55 module can exert its signaling function outside of the classical raft fraction of the cell membrane."xsd:string |
| http://purl.uniprot.org/citations/16980616 | http://purl.org/dc/terms/identifier | "doi:10.1128/mcb.00331-06"xsd:string |
| http://purl.uniprot.org/citations/16980616 | http://purl.org/dc/terms/identifier | "doi:10.1128/mcb.00331-06"xsd:string |
| http://purl.uniprot.org/citations/16980616 | http://purl.uniprot.org/core/author | "Wang X."xsd:string |
| http://purl.uniprot.org/citations/16980616 | http://purl.uniprot.org/core/author | "Wang X."xsd:string |
| http://purl.uniprot.org/citations/16980616 | http://purl.uniprot.org/core/author | "Kliche S."xsd:string |
| http://purl.uniprot.org/citations/16980616 | http://purl.uniprot.org/core/author | "Kliche S."xsd:string |
| http://purl.uniprot.org/citations/16980616 | http://purl.uniprot.org/core/author | "Freund C."xsd:string |
| http://purl.uniprot.org/citations/16980616 | http://purl.uniprot.org/core/author | "Freund C."xsd:string |
| http://purl.uniprot.org/citations/16980616 | http://purl.uniprot.org/core/author | "Schraven B."xsd:string |
| http://purl.uniprot.org/citations/16980616 | http://purl.uniprot.org/core/author | "Schraven B."xsd:string |
| http://purl.uniprot.org/citations/16980616 | http://purl.uniprot.org/core/author | "Koretzky G.A."xsd:string |
| http://purl.uniprot.org/citations/16980616 | http://purl.uniprot.org/core/author | "Koretzky G.A."xsd:string |
| http://purl.uniprot.org/citations/16980616 | http://purl.uniprot.org/core/author | "Breitling D."xsd:string |
| http://purl.uniprot.org/citations/16980616 | http://purl.uniprot.org/core/author | "Breitling D."xsd:string |
| http://purl.uniprot.org/citations/16980616 | http://purl.uniprot.org/core/author | "Heuer K."xsd:string |
| http://purl.uniprot.org/citations/16980616 | http://purl.uniprot.org/core/author | "Heuer K."xsd:string |
| http://purl.uniprot.org/citations/16980616 | http://purl.uniprot.org/core/author | "Kasirer-Friede A."xsd:string |
| http://purl.uniprot.org/citations/16980616 | http://purl.uniprot.org/core/author | "Kasirer-Friede A."xsd:string |
| http://purl.uniprot.org/citations/16980616 | http://purl.uniprot.org/core/author | "Menasche G."xsd:string |
| http://purl.uniprot.org/citations/16980616 | http://purl.uniprot.org/core/author | "Menasche G."xsd:string |
| http://purl.uniprot.org/citations/16980616 | http://purl.uniprot.org/core/author | "Pusch R."xsd:string |
| http://purl.uniprot.org/citations/16980616 | http://purl.uniprot.org/core/author | "Pusch R."xsd:string |