| http://purl.uniprot.org/citations/17001072 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17001072 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17001072 | http://www.w3.org/2000/01/rdf-schema#comment | "Retroviruses/retroelements provide tools enabling the identification and dissection of basic steps for post-transcriptional regulation of cellular mRNAs. The RNA transport element (RTE) identified in mouse retrotransposons is functionally equivalent to constitutive transport element of Type D retroviruses, yet does not bind directly to the mRNA export receptor NXF1. Here, we report that the RNA-binding motif protein 15 (RBM15) recognizes RTE directly and specifically in vitro and stimulates export and expression of RTE-containing reporter mRNAs in vivo. Tethering of RBM15 to a reporter mRNA showed that RBM15 acts by promoting mRNA export from the nucleus. We also found that RBM15 binds to NXF1 and the two proteins cooperate in stimulating RTE-mediated mRNA export and expression. Thus, RBM15 is a novel mRNA export factor and is part of the NXF1 pathway. We propose that RTE evolved as a high affinity RBM15 ligand to provide a splicing-independent link to NXF1, thereby ensuring efficient nuclear export and expression of retrotransposon transcripts."xsd:string |
| http://purl.uniprot.org/citations/17001072 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m608745200"xsd:string |
| http://purl.uniprot.org/citations/17001072 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m608745200"xsd:string |
| http://purl.uniprot.org/citations/17001072 | http://purl.uniprot.org/core/author | "Felber B.K."xsd:string |
| http://purl.uniprot.org/citations/17001072 | http://purl.uniprot.org/core/author | "Felber B.K."xsd:string |
| http://purl.uniprot.org/citations/17001072 | http://purl.uniprot.org/core/author | "Pavlakis G.N."xsd:string |
| http://purl.uniprot.org/citations/17001072 | http://purl.uniprot.org/core/author | "Pavlakis G.N."xsd:string |
| http://purl.uniprot.org/citations/17001072 | http://purl.uniprot.org/core/author | "Uranishi H."xsd:string |
| http://purl.uniprot.org/citations/17001072 | http://purl.uniprot.org/core/author | "Uranishi H."xsd:string |
| http://purl.uniprot.org/citations/17001072 | http://purl.uniprot.org/core/author | "Panayotou G."xsd:string |
| http://purl.uniprot.org/citations/17001072 | http://purl.uniprot.org/core/author | "Panayotou G."xsd:string |
| http://purl.uniprot.org/citations/17001072 | http://purl.uniprot.org/core/author | "Samiotaki M."xsd:string |
| http://purl.uniprot.org/citations/17001072 | http://purl.uniprot.org/core/author | "Samiotaki M."xsd:string |
| http://purl.uniprot.org/citations/17001072 | http://purl.uniprot.org/core/author | "Bear J."xsd:string |
| http://purl.uniprot.org/citations/17001072 | http://purl.uniprot.org/core/author | "Bear J."xsd:string |
| http://purl.uniprot.org/citations/17001072 | http://purl.uniprot.org/core/author | "Kulkarni V."xsd:string |
| http://purl.uniprot.org/citations/17001072 | http://purl.uniprot.org/core/author | "Kulkarni V."xsd:string |
| http://purl.uniprot.org/citations/17001072 | http://purl.uniprot.org/core/author | "Lindtner S."xsd:string |
| http://purl.uniprot.org/citations/17001072 | http://purl.uniprot.org/core/author | "Lindtner S."xsd:string |
| http://purl.uniprot.org/citations/17001072 | http://purl.uniprot.org/core/author | "Smulevitch S."xsd:string |
| http://purl.uniprot.org/citations/17001072 | http://purl.uniprot.org/core/author | "Smulevitch S."xsd:string |
| http://purl.uniprot.org/citations/17001072 | http://purl.uniprot.org/core/author | "Zolotukhin A.S."xsd:string |
| http://purl.uniprot.org/citations/17001072 | http://purl.uniprot.org/core/author | "Zolotukhin A.S."xsd:string |