| http://purl.uniprot.org/citations/17018279 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17018279 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17018279 | http://www.w3.org/2000/01/rdf-schema#comment | "The canonical conformational states occupied by most ligand-gated ion channels, and many cell-surface receptors, are the resting, activated, and desensitized states. While the resting and activated states of multiple receptors are well characterized, elaboration of the structural properties of the desensitized state, a state that is by definition inactive, has proven difficult. Here we use electrical, chemical, and crystallographic experiments on the AMPA-sensitive GluR2 receptor, defining the conformational rearrangements of the agonist binding cores that occur upon desensitization of this ligand-gated ion channel. These studies demonstrate that desensitization involves the rupture of an extensive interface between domain 1 of 2-fold related glutamate-binding core subunits, compensating for the ca. 21 degrees of domain closure induced by glutamate binding. The rupture of the domain 1 interface allows the ion channel to close and thereby provides a simple explanation to the long-standing question of how agonist binding is decoupled from ion channel gating upon receptor desensitization."xsd:string |
| http://purl.uniprot.org/citations/17018279 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.cell.2006.08.037"xsd:string |
| http://purl.uniprot.org/citations/17018279 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.cell.2006.08.037"xsd:string |
| http://purl.uniprot.org/citations/17018279 | http://purl.uniprot.org/core/author | "Gouaux E."xsd:string |
| http://purl.uniprot.org/citations/17018279 | http://purl.uniprot.org/core/author | "Gouaux E."xsd:string |
| http://purl.uniprot.org/citations/17018279 | http://purl.uniprot.org/core/author | "Jasti J."xsd:string |
| http://purl.uniprot.org/citations/17018279 | http://purl.uniprot.org/core/author | "Jasti J."xsd:string |
| http://purl.uniprot.org/citations/17018279 | http://purl.uniprot.org/core/author | "Armstrong N."xsd:string |
| http://purl.uniprot.org/citations/17018279 | http://purl.uniprot.org/core/author | "Armstrong N."xsd:string |
| http://purl.uniprot.org/citations/17018279 | http://purl.uniprot.org/core/author | "Beich-Frandsen M."xsd:string |
| http://purl.uniprot.org/citations/17018279 | http://purl.uniprot.org/core/author | "Beich-Frandsen M."xsd:string |
| http://purl.uniprot.org/citations/17018279 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/17018279 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/17018279 | http://purl.uniprot.org/core/name | "Cell"xsd:string |
| http://purl.uniprot.org/citations/17018279 | http://purl.uniprot.org/core/name | "Cell"xsd:string |
| http://purl.uniprot.org/citations/17018279 | http://purl.uniprot.org/core/pages | "85-97"xsd:string |
| http://purl.uniprot.org/citations/17018279 | http://purl.uniprot.org/core/pages | "85-97"xsd:string |
| http://purl.uniprot.org/citations/17018279 | http://purl.uniprot.org/core/title | "Measurement of conformational changes accompanying desensitization in an ionotropic glutamate receptor."xsd:string |
| http://purl.uniprot.org/citations/17018279 | http://purl.uniprot.org/core/title | "Measurement of conformational changes accompanying desensitization in an ionotropic glutamate receptor."xsd:string |
| http://purl.uniprot.org/citations/17018279 | http://purl.uniprot.org/core/volume | "127"xsd:string |
| http://purl.uniprot.org/citations/17018279 | http://purl.uniprot.org/core/volume | "127"xsd:string |
| http://purl.uniprot.org/citations/17018279 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/17018279 |
| http://purl.uniprot.org/citations/17018279 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/17018279 |