| http://purl.uniprot.org/citations/17020950 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17020950 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17020950 | http://www.w3.org/2000/01/rdf-schema#comment | "Antiviral innate immune responses can be triggered by accumulation of intracellular nucleic acids resulting from virus infections. Double-stranded RNA (dsRNA) can be detected by the cytoplasmic RNA helicase proteins RIG-I and MDA5, two proteins that share sequence similarities within a caspase recruitment domain (CARD) and a DExD/H box RNA helicase domain. These proteins are considered dsRNA sensors and are thought to transmit the signal to the mitochondrial adapter, IPS-1 (also known as MAVS, VISA, or CARDIF) via CARD interactions. IPS-1 coordinates the activity of protein kinases that activate transcription factors needed to induce beta interferon (IFN-beta) gene transcription. Another helicase protein, LGP2, lacks the CARD region and does not activate IFN-beta gene expression. LGP2 mRNA is induced by interferon, dsRNA treatments, or Sendai virus infection and acts as a feedback inhibitor for antiviral signaling. Results indicate that LGP2 can inhibit antiviral signaling independently of dsRNA or virus infection intermediates by engaging in a protein complex with IPS-1. Experiments suggest that LGP2 can compete with the kinase IKKi (also known as IKKepsilon) for a common interaction site on IPS-1. These results provide the first demonstration of protein interaction as an element of negative-feedback regulation of intracellular antiviral signaling by LGP2."xsd:string |
| http://purl.uniprot.org/citations/17020950 | http://purl.org/dc/terms/identifier | "doi:10.1128/jvi.01325-06"xsd:string |
| http://purl.uniprot.org/citations/17020950 | http://purl.org/dc/terms/identifier | "doi:10.1128/jvi.01325-06"xsd:string |
| http://purl.uniprot.org/citations/17020950 | http://purl.uniprot.org/core/author | "Komuro A."xsd:string |
| http://purl.uniprot.org/citations/17020950 | http://purl.uniprot.org/core/author | "Komuro A."xsd:string |
| http://purl.uniprot.org/citations/17020950 | http://purl.uniprot.org/core/author | "Horvath C.M."xsd:string |
| http://purl.uniprot.org/citations/17020950 | http://purl.uniprot.org/core/author | "Horvath C.M."xsd:string |
| http://purl.uniprot.org/citations/17020950 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/17020950 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/17020950 | http://purl.uniprot.org/core/name | "J. Virol."xsd:string |
| http://purl.uniprot.org/citations/17020950 | http://purl.uniprot.org/core/name | "J. Virol."xsd:string |
| http://purl.uniprot.org/citations/17020950 | http://purl.uniprot.org/core/pages | "12332-12342"xsd:string |
| http://purl.uniprot.org/citations/17020950 | http://purl.uniprot.org/core/pages | "12332-12342"xsd:string |
| http://purl.uniprot.org/citations/17020950 | http://purl.uniprot.org/core/title | "RNA- and virus-independent inhibition of antiviral signaling by RNA helicase LGP2."xsd:string |
| http://purl.uniprot.org/citations/17020950 | http://purl.uniprot.org/core/title | "RNA- and virus-independent inhibition of antiviral signaling by RNA helicase LGP2."xsd:string |
| http://purl.uniprot.org/citations/17020950 | http://purl.uniprot.org/core/volume | "80"xsd:string |
| http://purl.uniprot.org/citations/17020950 | http://purl.uniprot.org/core/volume | "80"xsd:string |
| http://purl.uniprot.org/citations/17020950 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/17020950 |
| http://purl.uniprot.org/citations/17020950 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/17020950 |
| http://purl.uniprot.org/citations/17020950 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/17020950 |
| http://purl.uniprot.org/citations/17020950 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/17020950 |
| http://purl.uniprot.org/uniprot/Q7Z434 | http://purl.uniprot.org/core/citation | http://purl.uniprot.org/citations/17020950 |
| http://purl.uniprot.org/uniprot/Q96C10 | http://purl.uniprot.org/core/citation | http://purl.uniprot.org/citations/17020950 |