| http://purl.uniprot.org/citations/1702217 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/1702217 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/1702217 | http://www.w3.org/2000/01/rdf-schema#comment | "Using the mouse interleukin 3 (IL-3) receptor cDNA as a probe, we obtained a homologous cDNA (KH97) from a cDNA library of a human hemopoietic cell line, TF-1. The protein encoded by the KH97 cDNA has 56% amino acid sequence identity with the mouse IL-3 receptor and retains features common to the family of cytokine receptors. Fibroblasts transfected with the KH97 cDNA expressed a protein of 120 kDa but did not bind any human cytokines, including IL-3 and granulocyte-macrophage colony-stimulating factor (GM-CSF). Interestingly, cotransfection of cDNAs for KH97 and the low-affinity human GM-CSF receptor in fibroblasts resulted in formation of a high-affinity receptor for GM-CSF. The dissociation rate of GM-CSF from the reconstituted high-affinity receptor was slower than that from the low-affinity site, whereas the association rate was unchanged. Cross-linking of 125I-labeled GM-CSF to fibroblasts cotransfected with both cDNAs revealed the same cross-linking patterns as in TF-1 cells--i.e., two major proteins of 80 and 120 kDa which correspond to the low-affinity GM-CSF receptor and the KH97 protein, respectively. These results indicate that the high-affinity GM-CSF receptor is composed of at least two components in a manner analogous to the IL-2 receptor. We therefore propose to designate the low-affinity GM-CSF receptor and the KH97 protein as the alpha and beta subunits of the GM-CSF receptor, respectively."xsd:string |
| http://purl.uniprot.org/citations/1702217 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.87.24.9655"xsd:string |
| http://purl.uniprot.org/citations/1702217 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.87.24.9655"xsd:string |
| http://purl.uniprot.org/citations/1702217 | http://purl.uniprot.org/core/author | "Arai K."xsd:string |
| http://purl.uniprot.org/citations/1702217 | http://purl.uniprot.org/core/author | "Arai K."xsd:string |
| http://purl.uniprot.org/citations/1702217 | http://purl.uniprot.org/core/author | "Hayashida K."xsd:string |
| http://purl.uniprot.org/citations/1702217 | http://purl.uniprot.org/core/author | "Hayashida K."xsd:string |
| http://purl.uniprot.org/citations/1702217 | http://purl.uniprot.org/core/author | "Kitamura T."xsd:string |
| http://purl.uniprot.org/citations/1702217 | http://purl.uniprot.org/core/author | "Kitamura T."xsd:string |
| http://purl.uniprot.org/citations/1702217 | http://purl.uniprot.org/core/author | "Yokota T."xsd:string |
| http://purl.uniprot.org/citations/1702217 | http://purl.uniprot.org/core/author | "Yokota T."xsd:string |
| http://purl.uniprot.org/citations/1702217 | http://purl.uniprot.org/core/author | "Miyajima A."xsd:string |
| http://purl.uniprot.org/citations/1702217 | http://purl.uniprot.org/core/author | "Miyajima A."xsd:string |
| http://purl.uniprot.org/citations/1702217 | http://purl.uniprot.org/core/author | "Gorman D.M."xsd:string |
| http://purl.uniprot.org/citations/1702217 | http://purl.uniprot.org/core/author | "Gorman D.M."xsd:string |
| http://purl.uniprot.org/citations/1702217 | http://purl.uniprot.org/core/date | "1990"xsd:gYear |
| http://purl.uniprot.org/citations/1702217 | http://purl.uniprot.org/core/date | "1990"xsd:gYear |
| http://purl.uniprot.org/citations/1702217 | http://purl.uniprot.org/core/name | "Proc. Natl. Acad. Sci. U.S.A."xsd:string |
| http://purl.uniprot.org/citations/1702217 | http://purl.uniprot.org/core/name | "Proc. Natl. Acad. Sci. U.S.A."xsd:string |
| http://purl.uniprot.org/citations/1702217 | http://purl.uniprot.org/core/pages | "9655-9659"xsd:string |
| http://purl.uniprot.org/citations/1702217 | http://purl.uniprot.org/core/pages | "9655-9659"xsd:string |
| http://purl.uniprot.org/citations/1702217 | http://purl.uniprot.org/core/title | "Molecular cloning of a second subunit of the receptor for human granulocyte-macrophage colony-stimulating factor (GM-CSF): reconstitution of a high-affinity GM-CSF receptor."xsd:string |
| http://purl.uniprot.org/citations/1702217 | http://purl.uniprot.org/core/title | "Molecular cloning of a second subunit of the receptor for human granulocyte-macrophage colony-stimulating factor (GM-CSF): reconstitution of a high-affinity GM-CSF receptor."xsd:string |