| http://purl.uniprot.org/citations/17031575 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17031575 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17031575 | http://www.w3.org/2000/01/rdf-schema#comment | "Bladder cancer-associated protein gene (BLCAP) is a novel candidate tumor suppressor gene identified from the human bladder carcinoma. Our previous studies have shown that BLCAP overexpression could inhibit cell growth by inducing apoptosis in HeLa cells [Zuo Z, Zhao M, Liu J, Gao G, Wu X: Tumor Biol 27: 221-226, 2006]. Such evidence suggests the alterations in BLCAP may play an important role in tumorigenesis. To further study the biological function of the BLCAP gene, we constructed a recombinant retroviral vector encoding BLCAP cDNA. Overexpressed BLCAP, via stable infection of exogenous BLCAP, resulted in growth inhibition of the human tongue cancer cell line Tca8113 in vitro, accompanied by S phase cell cycle arrest and apoptosis. The growth inhibition was correlated with up-regulation of p21(WAF1/CIP1 )expression and down-regulation of Bcl-XL and Bcl-2 expressions. However, p53 expression and NF-kappaB activity remained unchanged post infection. Furthermore, no changes in p53 phosphorylation at Ser46 and nuclear localization, which are critical to p53 function, were observed in BLCAP-overexpressed cells. Taken together, BLCAP may play a role not only in regulating cell proliferation but also in coordinating apoptosis and cell cycle via a novel way independent of p53 and NF-kappaB."xsd:string |
| http://purl.uniprot.org/citations/17031575 | http://purl.org/dc/terms/identifier | "doi:10.1007/s11010-006-9332-2"xsd:string |
| http://purl.uniprot.org/citations/17031575 | http://purl.org/dc/terms/identifier | "doi:10.1007/s11010-006-9332-2"xsd:string |
| http://purl.uniprot.org/citations/17031575 | http://purl.uniprot.org/core/author | "Fan M."xsd:string |
| http://purl.uniprot.org/citations/17031575 | http://purl.uniprot.org/core/author | "Fan M."xsd:string |
| http://purl.uniprot.org/citations/17031575 | http://purl.uniprot.org/core/author | "Wu X."xsd:string |
| http://purl.uniprot.org/citations/17031575 | http://purl.uniprot.org/core/author | "Wu X."xsd:string |
| http://purl.uniprot.org/citations/17031575 | http://purl.uniprot.org/core/author | "Yuan J."xsd:string |
| http://purl.uniprot.org/citations/17031575 | http://purl.uniprot.org/core/author | "Yuan J."xsd:string |
| http://purl.uniprot.org/citations/17031575 | http://purl.uniprot.org/core/author | "Duan L."xsd:string |
| http://purl.uniprot.org/citations/17031575 | http://purl.uniprot.org/core/author | "Duan L."xsd:string |
| http://purl.uniprot.org/citations/17031575 | http://purl.uniprot.org/core/author | "Yao J."xsd:string |
| http://purl.uniprot.org/citations/17031575 | http://purl.uniprot.org/core/author | "Yao J."xsd:string |
| http://purl.uniprot.org/citations/17031575 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17031575 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17031575 | http://purl.uniprot.org/core/name | "Mol. Cell. Biochem."xsd:string |
| http://purl.uniprot.org/citations/17031575 | http://purl.uniprot.org/core/name | "Mol. Cell. Biochem."xsd:string |
| http://purl.uniprot.org/citations/17031575 | http://purl.uniprot.org/core/pages | "81-92"xsd:string |
| http://purl.uniprot.org/citations/17031575 | http://purl.uniprot.org/core/pages | "81-92"xsd:string |
| http://purl.uniprot.org/citations/17031575 | http://purl.uniprot.org/core/title | "Overexpression of BLCAP induces S phase arrest and apoptosis independent of p53 and NF-kappaB in human tongue carcinoma: BLCAP overexpression induces S phase arrest and apoptosis."xsd:string |
| http://purl.uniprot.org/citations/17031575 | http://purl.uniprot.org/core/title | "Overexpression of BLCAP induces S phase arrest and apoptosis independent of p53 and NF-kappaB in human tongue carcinoma: BLCAP overexpression induces S phase arrest and apoptosis."xsd:string |
| http://purl.uniprot.org/citations/17031575 | http://purl.uniprot.org/core/volume | "297"xsd:string |
| http://purl.uniprot.org/citations/17031575 | http://purl.uniprot.org/core/volume | "297"xsd:string |