| http://purl.uniprot.org/citations/17066076 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17066076 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17066076 | http://www.w3.org/2000/01/rdf-schema#comment | "In mammalian cells, DNA methylation is associated with heritable and stable gene repression, mediated in part by methyl-CpG-binding domain (MBD) proteins that recruit corepressors to modify chromatin. MBD1 protein, a member of the MBD family, forms a complex with SETDB1 histone methylase to silence transcription at target promoters by methylation of lysine 9 of histone H3. How MBD1-mediated transcriptional repression is regulated is currently unknown. Here we show that MBD1 is a target for sumoylation by PIAS1 (Protein Inhibitors of Activated STAT 1) and PIAS3 E3 SUMO (small ubiquitin-like modifier)-ligases, at two conserved lysine residues within the C-terminus of MBD1. Although sumoylated MBD1 binds to methylated DNA, it does not incorporate into a complex with SETDB1 and does not efficiently repress transcription of a target gene, p53BP2, in HeLa cells. Our data suggest that transcriptional silencing by MBD1 is regulated by a PIAS-mediated conjugation of SUMO1, which antagonizes the formation of a repressive complex with SETDB1."xsd:string |
| http://purl.uniprot.org/citations/17066076 | http://purl.org/dc/terms/identifier | "doi:10.1038/sj.emboj.7601404"xsd:string |
| http://purl.uniprot.org/citations/17066076 | http://purl.org/dc/terms/identifier | "doi:10.1038/sj.emboj.7601404"xsd:string |
| http://purl.uniprot.org/citations/17066076 | http://purl.uniprot.org/core/author | "Nan X."xsd:string |
| http://purl.uniprot.org/citations/17066076 | http://purl.uniprot.org/core/author | "Nan X."xsd:string |
| http://purl.uniprot.org/citations/17066076 | http://purl.uniprot.org/core/author | "Stancheva I."xsd:string |
| http://purl.uniprot.org/citations/17066076 | http://purl.uniprot.org/core/author | "Stancheva I."xsd:string |
| http://purl.uniprot.org/citations/17066076 | http://purl.uniprot.org/core/author | "Lyst M.J."xsd:string |
| http://purl.uniprot.org/citations/17066076 | http://purl.uniprot.org/core/author | "Lyst M.J."xsd:string |
| http://purl.uniprot.org/citations/17066076 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/17066076 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/17066076 | http://purl.uniprot.org/core/name | "EMBO J."xsd:string |
| http://purl.uniprot.org/citations/17066076 | http://purl.uniprot.org/core/name | "EMBO J."xsd:string |
| http://purl.uniprot.org/citations/17066076 | http://purl.uniprot.org/core/pages | "5317-5328"xsd:string |
| http://purl.uniprot.org/citations/17066076 | http://purl.uniprot.org/core/pages | "5317-5328"xsd:string |
| http://purl.uniprot.org/citations/17066076 | http://purl.uniprot.org/core/title | "Regulation of MBD1-mediated transcriptional repression by SUMO and PIAS proteins."xsd:string |
| http://purl.uniprot.org/citations/17066076 | http://purl.uniprot.org/core/title | "Regulation of MBD1-mediated transcriptional repression by SUMO and PIAS proteins."xsd:string |
| http://purl.uniprot.org/citations/17066076 | http://purl.uniprot.org/core/volume | "25"xsd:string |
| http://purl.uniprot.org/citations/17066076 | http://purl.uniprot.org/core/volume | "25"xsd:string |
| http://purl.uniprot.org/citations/17066076 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/17066076 |
| http://purl.uniprot.org/citations/17066076 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/17066076 |
| http://purl.uniprot.org/citations/17066076 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/17066076 |
| http://purl.uniprot.org/citations/17066076 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/17066076 |