| http://purl.uniprot.org/citations/1707125 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/1707125 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/1707125 | http://www.w3.org/2000/01/rdf-schema#comment | "In this study we report the preparation of a human osteosarcoma cell cDNA library and describe the isolation and sequence determination of a clone encoding the complete sequence of a novel human insulin-like growth factor (IGF)-binding protein (hIGFBP-4). Previous work indicated that hIGFBP-4 is the predominant IGFBP expressed by human osteoblast-like cells, and that IGFBP-4 binds and inhibits the mitogenic activities of IGF-I and IGF-II. Sequence determination revealed that hIGFBP-4 is a unique gene product with significant amino- and carboxy-terminal sequence similarity to three other known IGFBPs. Identical alignment of 18 cysteines in IGFBP-4 and the three other IGFBPs is a key structural feature of this protein family. In vitro studies of human osteoblast-like cells suggest that PTH regulates the expression of hIGFBP-4 and that the PTH effect is mediated through a cAMP mechanism. hIGFBP-4 mRNA was also expressed in skin fibroblasts, and thus, this inhibitory IGFBP could be an important physiological regulator of IGF actions in bone cells and other cell types as well."xsd:string |
| http://purl.uniprot.org/citations/1707125 | http://purl.org/dc/terms/identifier | "doi:10.1210/mend-4-12-1806"xsd:string |
| http://purl.uniprot.org/citations/1707125 | http://purl.org/dc/terms/identifier | "doi:10.1210/mend-4-12-1806"xsd:string |
| http://purl.uniprot.org/citations/1707125 | http://purl.uniprot.org/core/author | "Mohan S."xsd:string |
| http://purl.uniprot.org/citations/1707125 | http://purl.uniprot.org/core/author | "Mohan S."xsd:string |
| http://purl.uniprot.org/citations/1707125 | http://purl.uniprot.org/core/author | "Baylink D.J."xsd:string |
| http://purl.uniprot.org/citations/1707125 | http://purl.uniprot.org/core/author | "Baylink D.J."xsd:string |
| http://purl.uniprot.org/citations/1707125 | http://purl.uniprot.org/core/author | "Strong D.D."xsd:string |
| http://purl.uniprot.org/citations/1707125 | http://purl.uniprot.org/core/author | "Strong D.D."xsd:string |
| http://purl.uniprot.org/citations/1707125 | http://purl.uniprot.org/core/author | "Latour D."xsd:string |
| http://purl.uniprot.org/citations/1707125 | http://purl.uniprot.org/core/author | "Latour D."xsd:string |
| http://purl.uniprot.org/citations/1707125 | http://purl.uniprot.org/core/author | "Linkhart T.A."xsd:string |
| http://purl.uniprot.org/citations/1707125 | http://purl.uniprot.org/core/author | "Linkhart T.A."xsd:string |
| http://purl.uniprot.org/citations/1707125 | http://purl.uniprot.org/core/date | "1990"xsd:gYear |
| http://purl.uniprot.org/citations/1707125 | http://purl.uniprot.org/core/date | "1990"xsd:gYear |
| http://purl.uniprot.org/citations/1707125 | http://purl.uniprot.org/core/name | "Mol. Endocrinol."xsd:string |
| http://purl.uniprot.org/citations/1707125 | http://purl.uniprot.org/core/name | "Mol. Endocrinol."xsd:string |
| http://purl.uniprot.org/citations/1707125 | http://purl.uniprot.org/core/pages | "1806-1814"xsd:string |
| http://purl.uniprot.org/citations/1707125 | http://purl.uniprot.org/core/pages | "1806-1814"xsd:string |
| http://purl.uniprot.org/citations/1707125 | http://purl.uniprot.org/core/title | "Inhibitory insulin-like growth factor-binding protein: cloning, complete sequence, and physiological regulation."xsd:string |
| http://purl.uniprot.org/citations/1707125 | http://purl.uniprot.org/core/title | "Inhibitory insulin-like growth factor-binding protein: cloning, complete sequence, and physiological regulation."xsd:string |
| http://purl.uniprot.org/citations/1707125 | http://purl.uniprot.org/core/volume | "4"xsd:string |
| http://purl.uniprot.org/citations/1707125 | http://purl.uniprot.org/core/volume | "4"xsd:string |