| http://purl.uniprot.org/citations/17098225 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17098225 | http://www.w3.org/2000/01/rdf-schema#comment | "The Caenorhabditis elegans daf-2/insulin-like signaling pathway is critical for regulating development, longevity, metabolism and stress resistance. We identified the 14-3-3 protein FTT-2 to be a new regulatory component of this pathway. We found that RNAi knock down of ftt-2 specifically enhanced the daf-2-mediated dauer formation phenotype. Furthermore, ftt-2 knock down caused the nuclear accumulation of DAF-16/FOXO, the forkhead transcription factor that is the major downstream effecter of daf-2/insulin-like signaling, and enhanced the transcriptional activities of DAF-16. In contrast to ftt-2, RNAi knock down of par-5/ftt-1, the only other gene predicted to encode a 14-3-3 protein in C. elegans, did not show any notable effect on dauer formation, DAF-16 localization, or DAF-16 downstream gene transcription, underscoring the functional specification of FTT-2 and PAR-5 despite their high sequence homology. Using co-immunoprecipitation, we revealed that FTT-2 formed a complex with GFP-fused DAF-16 in C. elegans. Our results indicate that FTT-2 binds to DAF-16 in C. elegans and regulates DAF-16 by sequestering it in the cytoplasm. A similar mechanism of regulation of FOXO by 14-3-3zeta has been reported in mammalian cells, highlighting the high degree of conservation of the daf-2/insulin-like signaling pathway."xsd:string |
| http://purl.uniprot.org/citations/17098225 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.ydbio.2006.10.013"xsd:string |
| http://purl.uniprot.org/citations/17098225 | http://purl.uniprot.org/core/author | "Li J."xsd:string |
| http://purl.uniprot.org/citations/17098225 | http://purl.uniprot.org/core/author | "Lee S.S."xsd:string |
| http://purl.uniprot.org/citations/17098225 | http://purl.uniprot.org/core/author | "Vidal M."xsd:string |
| http://purl.uniprot.org/citations/17098225 | http://purl.uniprot.org/core/author | "Tewari M."xsd:string |
| http://purl.uniprot.org/citations/17098225 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17098225 | http://purl.uniprot.org/core/name | "Dev Biol"xsd:string |
| http://purl.uniprot.org/citations/17098225 | http://purl.uniprot.org/core/pages | "82-91"xsd:string |
| http://purl.uniprot.org/citations/17098225 | http://purl.uniprot.org/core/title | "The 14-3-3 protein FTT-2 regulates DAF-16 in Caenorhabditis elegans."xsd:string |
| http://purl.uniprot.org/citations/17098225 | http://purl.uniprot.org/core/volume | "301"xsd:string |
| http://purl.uniprot.org/citations/17098225 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/17098225 |
| http://purl.uniprot.org/citations/17098225 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/17098225 |
| http://purl.uniprot.org/uniprot/Q20655#attribution-0FB40B0721399BC878F3802FB293E1C6 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/17098225 |
| http://purl.uniprot.org/uniprot/Q20655#attribution-873EA3070D15A7D4B0F26396C29A4DC7 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/17098225 |
| http://purl.uniprot.org/uniprot/Q20655#attribution-C49EBB0073AA85A73A1B9C91B7FED058 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/17098225 |
| http://purl.uniprot.org/uniprot/Q20655#attribution-E35867A82519125B43EB9B2DE590A673 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/17098225 |
| http://purl.uniprot.org/uniprot/O16850#attribution-873EA3070D15A7D4B0F26396C29A4DC7 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/17098225 |
| http://purl.uniprot.org/uniprot/#_A0A0K3AWG6-mappedCitation-17098225 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17098225 |
| http://purl.uniprot.org/uniprot/#_A0A0K3AR63-mappedCitation-17098225 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17098225 |
| http://purl.uniprot.org/uniprot/#_A0A0K3AR95-mappedCitation-17098225 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17098225 |
| http://purl.uniprot.org/uniprot/#_A0A0K3ATP5-mappedCitation-17098225 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17098225 |
| http://purl.uniprot.org/uniprot/#_P41932-mappedCitation-17098225 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17098225 |
| http://purl.uniprot.org/uniprot/#_N1NV25-mappedCitation-17098225 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17098225 |