| http://purl.uniprot.org/citations/17116881 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17116881 | http://www.w3.org/2000/01/rdf-schema#comment | "Apoptosis-inducing factor (AIF), a mitochondrial oxidoreductase, is released into the cytoplasm to induce cell death in response to poly(ADP-ribose) (PAR) polymerase-1 (PARP-1) activation. How PARP-1 activation leads to AIF release is not known. Here we identify PAR polymer as a cell death signal that induces release of AIF. PAR polymer induces mitochondrial AIF release and translocation to the nucleus. PAR glycohydrolase, which degrades PAR polymer, prevents PARP-1-dependent AIF release. Cells with reduced levels of AIF are resistant to PARP-1-dependent cell death and PAR polymer cytotoxicity. These results reveal PAR polymer as an AIF-releasing factor that plays important roles in PARP-1-dependent cell death."xsd:string |
| http://purl.uniprot.org/citations/17116881 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.0606528103"xsd:string |
| http://purl.uniprot.org/citations/17116881 | http://purl.uniprot.org/core/author | "Wang H."xsd:string |
| http://purl.uniprot.org/citations/17116881 | http://purl.uniprot.org/core/author | "Andrabi S.A."xsd:string |
| http://purl.uniprot.org/citations/17116881 | http://purl.uniprot.org/core/author | "Dawson T.M."xsd:string |
| http://purl.uniprot.org/citations/17116881 | http://purl.uniprot.org/core/author | "Dawson V.L."xsd:string |
| http://purl.uniprot.org/citations/17116881 | http://purl.uniprot.org/core/author | "Kim N.S."xsd:string |
| http://purl.uniprot.org/citations/17116881 | http://purl.uniprot.org/core/author | "Poirier G.G."xsd:string |
| http://purl.uniprot.org/citations/17116881 | http://purl.uniprot.org/core/author | "Yu S.W."xsd:string |
| http://purl.uniprot.org/citations/17116881 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/17116881 | http://purl.uniprot.org/core/name | "Proc Natl Acad Sci U S A"xsd:string |
| http://purl.uniprot.org/citations/17116881 | http://purl.uniprot.org/core/pages | "18314-18319"xsd:string |
| http://purl.uniprot.org/citations/17116881 | http://purl.uniprot.org/core/title | "Apoptosis-inducing factor mediates poly(ADP-ribose) (PAR) polymer-induced cell death."xsd:string |
| http://purl.uniprot.org/citations/17116881 | http://purl.uniprot.org/core/volume | "103"xsd:string |
| http://purl.uniprot.org/citations/17116881 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/17116881 |
| http://purl.uniprot.org/citations/17116881 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/17116881 |
| http://purl.uniprot.org/uniprot/#_A0A0A6YVX0-mappedCitation-17116881 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17116881 |
| http://purl.uniprot.org/uniprot/#_A0A0A6YX03-mappedCitation-17116881 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17116881 |
| http://purl.uniprot.org/uniprot/#_A0A0A6YY63-mappedCitation-17116881 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17116881 |
| http://purl.uniprot.org/uniprot/#_P11103-mappedCitation-17116881 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17116881 |
| http://purl.uniprot.org/uniprot/#_Q3U868-mappedCitation-17116881 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17116881 |
| http://purl.uniprot.org/uniprot/#_Q3TX36-mappedCitation-17116881 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17116881 |
| http://purl.uniprot.org/uniprot/#_Q921K2-mappedCitation-17116881 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17116881 |
| http://purl.uniprot.org/uniprot/#_Q3UJ03-mappedCitation-17116881 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17116881 |