| http://purl.uniprot.org/citations/17142736 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17142736 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17142736 | http://www.w3.org/2000/01/rdf-schema#comment | "The heat shock response is a canonical regulatory pathway by which cellular stressors such as heat and oxidative stress alter the expression of stress-responsive genes. Some of these stress-responsive genes (heat shock proteins and MHC class I (MHC I)-related chains) play a significant role in the immune system. In this study, we have investigated the impact of stimulating the heat shock response on genes involved in the MHC I presentation pathway. We report that two inducible subunits of the proteasome, lmp2 and lmp7, are transcriptionally up-regulated by heat shock in cells of mouse and human origin. Furthermore, heat-shocked cells show enhanced presentation of the immunoproteasome-dependent MHC I antigenic epitopes NP(118-126) of lymphocytic choriomeningitis virus and E1B(192-200) of adenovirus, but not immunoproteasome-independent epitopes such as tumor Ag AH1 and SV40 large T Ag epitope II(223-231). These findings show a novel immunological sequel to the cellular response to stress that may play a key role during fever or other homeostatic perturbations."xsd:string |
| http://purl.uniprot.org/citations/17142736 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.177.12.8393"xsd:string |
| http://purl.uniprot.org/citations/17142736 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.177.12.8393"xsd:string |
| http://purl.uniprot.org/citations/17142736 | http://purl.uniprot.org/core/author | "Menoret A."xsd:string |
| http://purl.uniprot.org/citations/17142736 | http://purl.uniprot.org/core/author | "Menoret A."xsd:string |
| http://purl.uniprot.org/citations/17142736 | http://purl.uniprot.org/core/author | "Srivastava P.K."xsd:string |
| http://purl.uniprot.org/citations/17142736 | http://purl.uniprot.org/core/author | "Srivastava P.K."xsd:string |
| http://purl.uniprot.org/citations/17142736 | http://purl.uniprot.org/core/author | "Callahan M.K."xsd:string |
| http://purl.uniprot.org/citations/17142736 | http://purl.uniprot.org/core/author | "Callahan M.K."xsd:string |
| http://purl.uniprot.org/citations/17142736 | http://purl.uniprot.org/core/author | "Wohlfert E.A."xsd:string |
| http://purl.uniprot.org/citations/17142736 | http://purl.uniprot.org/core/author | "Wohlfert E.A."xsd:string |
| http://purl.uniprot.org/citations/17142736 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/17142736 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/17142736 | http://purl.uniprot.org/core/name | "J. Immunol."xsd:string |
| http://purl.uniprot.org/citations/17142736 | http://purl.uniprot.org/core/name | "J. Immunol."xsd:string |
| http://purl.uniprot.org/citations/17142736 | http://purl.uniprot.org/core/pages | "8393-8399"xsd:string |
| http://purl.uniprot.org/citations/17142736 | http://purl.uniprot.org/core/pages | "8393-8399"xsd:string |
| http://purl.uniprot.org/citations/17142736 | http://purl.uniprot.org/core/title | "Heat shock up-regulates lmp2 and lmp7 and enhances presentation of immunoproteasome-dependent epitopes."xsd:string |
| http://purl.uniprot.org/citations/17142736 | http://purl.uniprot.org/core/title | "Heat shock up-regulates lmp2 and lmp7 and enhances presentation of immunoproteasome-dependent epitopes."xsd:string |
| http://purl.uniprot.org/citations/17142736 | http://purl.uniprot.org/core/volume | "177"xsd:string |
| http://purl.uniprot.org/citations/17142736 | http://purl.uniprot.org/core/volume | "177"xsd:string |
| http://purl.uniprot.org/citations/17142736 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/17142736 |
| http://purl.uniprot.org/citations/17142736 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/17142736 |