| http://purl.uniprot.org/citations/17145509 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17145509 | http://www.w3.org/2000/01/rdf-schema#comment | "Dopamine-glutamate interactions in the neostriatum determine psychostimulant action, but the underlying molecular mechanisms remain elusive. Here we found that dopamine stimulation by cocaine enhances a heteroreceptor complex formation between dopamine D2 receptors (D2R) and NMDA receptor NR2B subunits in the neostriatum in vivo. The D2R-NR2B interaction is direct and occurs in the confined postsynaptic density microdomain of excitatory synapses. The enhanced D2R-NR2B interaction disrupts the association of Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) with NR2B, reduces NR2B phosphorylation at a CaMKII-sensitive site (Ser1303), and inhibits NMDA receptor-mediated currents in medium-sized striatal neurons. Furthermore, the regulated D2R-NR2B interaction is critical for constructing behavioral responsiveness to cocaine. Our findings here uncover a direct and dynamic D2R-NR2B interaction in striatal neurons in vivo. This type of dopamine-glutamate integration at the receptor level may be responsible for synergistically inhibiting the D2R-mediated circuits in the basal ganglia and fulfilling the stimulative effect of psychostimulants."xsd:string |
| http://purl.uniprot.org/citations/17145509 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.neuron.2006.10.011"xsd:string |
| http://purl.uniprot.org/citations/17145509 | http://purl.uniprot.org/core/author | "Liu F."xsd:string |
| http://purl.uniprot.org/citations/17145509 | http://purl.uniprot.org/core/author | "Wang M."xsd:string |
| http://purl.uniprot.org/citations/17145509 | http://purl.uniprot.org/core/author | "Li M.H."xsd:string |
| http://purl.uniprot.org/citations/17145509 | http://purl.uniprot.org/core/author | "Neve K.A."xsd:string |
| http://purl.uniprot.org/citations/17145509 | http://purl.uniprot.org/core/author | "Liu X.Y."xsd:string |
| http://purl.uniprot.org/citations/17145509 | http://purl.uniprot.org/core/author | "Zhang G.C."xsd:string |
| http://purl.uniprot.org/citations/17145509 | http://purl.uniprot.org/core/author | "Wang J.Q."xsd:string |
| http://purl.uniprot.org/citations/17145509 | http://purl.uniprot.org/core/author | "Haines M."xsd:string |
| http://purl.uniprot.org/citations/17145509 | http://purl.uniprot.org/core/author | "Parelkar N.K."xsd:string |
| http://purl.uniprot.org/citations/17145509 | http://purl.uniprot.org/core/author | "Lan H.X."xsd:string |
| http://purl.uniprot.org/citations/17145509 | http://purl.uniprot.org/core/author | "Chu X.P."xsd:string |
| http://purl.uniprot.org/citations/17145509 | http://purl.uniprot.org/core/author | "Xiong Z.G."xsd:string |
| http://purl.uniprot.org/citations/17145509 | http://purl.uniprot.org/core/author | "Fibuch E.E."xsd:string |
| http://purl.uniprot.org/citations/17145509 | http://purl.uniprot.org/core/author | "Mao L.M."xsd:string |
| http://purl.uniprot.org/citations/17145509 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/17145509 | http://purl.uniprot.org/core/name | "Neuron"xsd:string |
| http://purl.uniprot.org/citations/17145509 | http://purl.uniprot.org/core/pages | "897-909"xsd:string |
| http://purl.uniprot.org/citations/17145509 | http://purl.uniprot.org/core/title | "Modulation of D2R-NR2B interactions in response to cocaine."xsd:string |
| http://purl.uniprot.org/citations/17145509 | http://purl.uniprot.org/core/volume | "52"xsd:string |
| http://purl.uniprot.org/citations/17145509 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/17145509 |
| http://purl.uniprot.org/citations/17145509 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/17145509 |
| http://purl.uniprot.org/uniprot/P61169#attribution-D10490852612FC0ECDFC769344ADBC15 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/17145509 |