| http://purl.uniprot.org/citations/17145956 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17145956 | http://www.w3.org/2000/01/rdf-schema#comment | "Colitis involves immune cell-mediated tissue injuries, but the contribution of epithelial cells remains largely unclear. Vanin-1 is an epithelial ectoenzyme with a pantetheinase activity that provides cysteamine/cystamine to tissue. Using the 2,4,6-trinitrobenzene sulfonic acid (TNBS)-colitis model we show here that Vanin-1 deficiency protects from colitis. This protection is reversible by administration of cystamine or bisphenol A diglycidyl ether, a peroxisome proliferator-activated receptor (PPAR)gamma antagonist. We further demonstrate that Vanin-1, by antagonizing PPARgamma, licenses the production of inflammatory mediators by intestinal epithelial cells. We propose that Vanin-1 is an epithelial sensor of stress that exerts a dominant control over innate immune responses in tissue. Thus, the Vanin-1/pantetheinase activity might be a new target for therapeutic intervention in inflammatory bowel disease."xsd:string |
| http://purl.uniprot.org/citations/17145956 | http://purl.org/dc/terms/identifier | "doi:10.1084/jem.20061640"xsd:string |
| http://purl.uniprot.org/citations/17145956 | http://purl.uniprot.org/core/author | "Garcia S."xsd:string |
| http://purl.uniprot.org/citations/17145956 | http://purl.uniprot.org/core/author | "Martin F.M."xsd:string |
| http://purl.uniprot.org/citations/17145956 | http://purl.uniprot.org/core/author | "Naquet P."xsd:string |
| http://purl.uniprot.org/citations/17145956 | http://purl.uniprot.org/core/author | "Galland F."xsd:string |
| http://purl.uniprot.org/citations/17145956 | http://purl.uniprot.org/core/author | "Bagnis C."xsd:string |
| http://purl.uniprot.org/citations/17145956 | http://purl.uniprot.org/core/author | "Pouyet L."xsd:string |
| http://purl.uniprot.org/citations/17145956 | http://purl.uniprot.org/core/author | "Millet V."xsd:string |
| http://purl.uniprot.org/citations/17145956 | http://purl.uniprot.org/core/author | "Berruyer C."xsd:string |
| http://purl.uniprot.org/citations/17145956 | http://purl.uniprot.org/core/author | "Canonici A."xsd:string |
| http://purl.uniprot.org/citations/17145956 | http://purl.uniprot.org/core/author | "LeGoffic A."xsd:string |
| http://purl.uniprot.org/citations/17145956 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/17145956 | http://purl.uniprot.org/core/name | "J Exp Med"xsd:string |
| http://purl.uniprot.org/citations/17145956 | http://purl.uniprot.org/core/pages | "2817-2827"xsd:string |
| http://purl.uniprot.org/citations/17145956 | http://purl.uniprot.org/core/title | "Vanin-1 licenses inflammatory mediator production by gut epithelial cells and controls colitis by antagonizing peroxisome proliferator-activated receptor gamma activity."xsd:string |
| http://purl.uniprot.org/citations/17145956 | http://purl.uniprot.org/core/volume | "203"xsd:string |
| http://purl.uniprot.org/citations/17145956 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/17145956 |
| http://purl.uniprot.org/citations/17145956 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/17145956 |
| http://purl.uniprot.org/uniprot/P37231#attribution-EA64A063DDC781A0F1843E247266E0C8 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/17145956 |
| http://purl.uniprot.org/uniprot/O95497#attribution-EA64A063DDC781A0F1843E247266E0C8 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/17145956 |
| http://purl.uniprot.org/uniprot/#_Q3UEK0-mappedCitation-17145956 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17145956 |
| http://purl.uniprot.org/uniprot/#_Q9Z0K8-mappedCitation-17145956 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17145956 |
| http://purl.uniprot.org/uniprot/Q9Z0K8 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/17145956 |