http://purl.uniprot.org/citations/17158641 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
http://purl.uniprot.org/citations/17158641 | http://www.w3.org/2000/01/rdf-schema#comment | "AimsTo analyse the correlation between MYC amplification and various clinicopathological features and outcome in a cohort of 245 patients with invasive breast carcinoma treated with surgery followed by anthracycline-based chemotherapy. Given the high prevalence of MYC amplification in tumours of BRCA1 mutation carriers and the similarities between these and sporadic "basal-like" carcinomas, the prevalence of MYC amplification in "basal-like" breast carcinomas was investigated.MethodsMYC gene copy number was assessed on tissue microarrays containing duplicate cores of 245 invasive breast carcinomas by means of chromogenic in situ hybridisation using SpotLight C-MYC amplification probe and chromosome 8 centromeric probe (CEP8). Signals were evaluated at 400x magnification; 30 morphologically unequivocal neoplastic cells in each core were counted for the presence of the gene and CEP8 probes.ResultsAmplification was defined as a MYC:CEP8 ratio >2. Signals for both MYC and CEP8 were assessable in 196/245 (80%) tumours. MYC amplification was found in 19/196 cases (9.7%) and was not associated with tumour size, histological grade, positivity for oestrogen receptor, progesterone receptor, HER2, epidermal growth factor, cytokeratins 14, 5/6 and 17, MIB1 or p53. Only 4% of basal-like carcinomas showed MYC amplification, compared to 8.75% and 10.7% of luminal and HER2 tumours respectively. On univariate analysis, MYC amplification displayed a significant association with shorter metastasis-free and overall survival and proved to be an independent prognostic factor on multivariate survival analysis.ConclusionMYC amplification is not associated with "basal-like" phenotype and proved to be an independent prognostic factor for breast cancer patients treated with anthracycline-based chemotherapy."xsd:string |
http://purl.uniprot.org/citations/17158641 | http://purl.org/dc/terms/identifier | "doi:10.1136/jcp.2006.043869"xsd:string |
http://purl.uniprot.org/citations/17158641 | http://purl.uniprot.org/core/author | "Jones R.L."xsd:string |
http://purl.uniprot.org/citations/17158641 | http://purl.uniprot.org/core/author | "James M."xsd:string |
http://purl.uniprot.org/citations/17158641 | http://purl.uniprot.org/core/author | "Pinder S.E."xsd:string |
http://purl.uniprot.org/citations/17158641 | http://purl.uniprot.org/core/author | "Savage K."xsd:string |
http://purl.uniprot.org/citations/17158641 | http://purl.uniprot.org/core/author | "Reis-Filho J.S."xsd:string |
http://purl.uniprot.org/citations/17158641 | http://purl.uniprot.org/core/author | "Rodriguez-Pinilla S.M."xsd:string |
http://purl.uniprot.org/citations/17158641 | http://purl.uniprot.org/core/author | "Arriola E."xsd:string |
http://purl.uniprot.org/citations/17158641 | http://purl.uniprot.org/core/author | "Lambros M.B."xsd:string |
http://purl.uniprot.org/citations/17158641 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
http://purl.uniprot.org/citations/17158641 | http://purl.uniprot.org/core/name | "J Clin Pathol"xsd:string |
http://purl.uniprot.org/citations/17158641 | http://purl.uniprot.org/core/pages | "1017-1023"xsd:string |
http://purl.uniprot.org/citations/17158641 | http://purl.uniprot.org/core/title | "MYC amplification in breast cancer: a chromogenic in situ hybridisation study."xsd:string |
http://purl.uniprot.org/citations/17158641 | http://purl.uniprot.org/core/volume | "60"xsd:string |
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