| http://purl.uniprot.org/citations/17159900 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17159900 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17159900 | http://www.w3.org/2000/01/rdf-schema#comment | "Upon DNA damage, a complex called the PIDDosome is formed and either signals NF-kappaB activation and thus cell survival or alternatively triggers caspase-2 activation and apoptosis. PIDD (p53-induced protein with a death domain) is constitutively processed giving rise to a 48-kDa N-terminal fragment containing the leucine-rich repeats (LRRs, PIDD-N) and a 51-kDa C-terminal fragment containing the death domain (DD, PIDD-C). The latter undergoes further cleavage resulting in a 37-kDa fragment (PIDD-CC). Here we show that processing occurs at S446 (generating PIDD-C) and S588 (generating PIDD-CC) by an auto-processing mechanism similar to that found in the nuclear pore protein Nup98/96 and inteins. Auto-cleavage of PIDD determines the outcome of the downstream signaling events. Whereas initially formed PIDD-C mediates the activation of NF-kappaB via the recruitment of RIP1 and NEMO, subsequent formation of PIDD-CC causes caspase-2 activation and thus cell death. A non-cleavable PIDD mutant is unable to translocate from the cytoplasm to the nucleus and loses both activities. In this way, auto-proteolysis of PIDD might participate in the orchestration of the DNA damage-induced life and death signaling pathways."xsd:string |
| http://purl.uniprot.org/citations/17159900 | http://purl.org/dc/terms/identifier | "doi:10.1038/sj.emboj.7601473"xsd:string |
| http://purl.uniprot.org/citations/17159900 | http://purl.org/dc/terms/identifier | "doi:10.1038/sj.emboj.7601473"xsd:string |
| http://purl.uniprot.org/citations/17159900 | http://purl.uniprot.org/core/author | "Quadroni M."xsd:string |
| http://purl.uniprot.org/citations/17159900 | http://purl.uniprot.org/core/author | "Quadroni M."xsd:string |
| http://purl.uniprot.org/citations/17159900 | http://purl.uniprot.org/core/author | "Tschopp J."xsd:string |
| http://purl.uniprot.org/citations/17159900 | http://purl.uniprot.org/core/author | "Tschopp J."xsd:string |
| http://purl.uniprot.org/citations/17159900 | http://purl.uniprot.org/core/author | "Janssens S."xsd:string |
| http://purl.uniprot.org/citations/17159900 | http://purl.uniprot.org/core/author | "Janssens S."xsd:string |
| http://purl.uniprot.org/citations/17159900 | http://purl.uniprot.org/core/author | "Lippens S."xsd:string |
| http://purl.uniprot.org/citations/17159900 | http://purl.uniprot.org/core/author | "Lippens S."xsd:string |
| http://purl.uniprot.org/citations/17159900 | http://purl.uniprot.org/core/author | "Tinel A."xsd:string |
| http://purl.uniprot.org/citations/17159900 | http://purl.uniprot.org/core/author | "Tinel A."xsd:string |
| http://purl.uniprot.org/citations/17159900 | http://purl.uniprot.org/core/author | "Cuenin S."xsd:string |
| http://purl.uniprot.org/citations/17159900 | http://purl.uniprot.org/core/author | "Cuenin S."xsd:string |
| http://purl.uniprot.org/citations/17159900 | http://purl.uniprot.org/core/author | "Jaccard B."xsd:string |
| http://purl.uniprot.org/citations/17159900 | http://purl.uniprot.org/core/author | "Jaccard B."xsd:string |
| http://purl.uniprot.org/citations/17159900 | http://purl.uniprot.org/core/author | "Logette E."xsd:string |
| http://purl.uniprot.org/citations/17159900 | http://purl.uniprot.org/core/author | "Logette E."xsd:string |
| http://purl.uniprot.org/citations/17159900 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17159900 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17159900 | http://purl.uniprot.org/core/name | "EMBO J."xsd:string |
| http://purl.uniprot.org/citations/17159900 | http://purl.uniprot.org/core/name | "EMBO J."xsd:string |