| http://purl.uniprot.org/citations/17159989 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17159989 | http://www.w3.org/2000/01/rdf-schema#comment | "Transforming growth factor beta (TGFbeta) is a potent trophic factor for midbrain dopamine (DA) neurons, but its in vivo function and signaling mechanisms are not entirely understood. We show that the transcriptional cofactor homeodomain interacting protein kinase 2 (HIPK2) is required for the TGFbeta-mediated survival of mouse DA neurons. The targeted deletion of Hipk2 has no deleterious effect on the neurogenesis of DA neurons, but leads to a selective loss of these neurons that is due to increased apoptosis during programmed cell death. As a consequence, Hipk2(-/-) mutants show an array of psychomotor abnormalities. The function of HIPK2 depends on its interaction with receptor-regulated Smads to activate TGFbeta target genes. In support of this notion, DA neurons from Hipk2(-/-) mutants fail to survive in the presence of TGFbeta3 and Tgfbeta3(-/-) mutants show DA neuron abnormalities similar to those seen in Hipk2(-/-) mutants. These data underscore the importance of the TGFbeta-Smad-HIPK2 pathway in the survival of DA neurons and its potential as a therapeutic target for promoting DA neuron survival during neurodegeneration."xsd:string |
| http://purl.uniprot.org/citations/17159989 | http://purl.org/dc/terms/identifier | "doi:10.1038/nn1816"xsd:string |
| http://purl.uniprot.org/citations/17159989 | http://purl.uniprot.org/core/author | "Zhang J."xsd:string |
| http://purl.uniprot.org/citations/17159989 | http://purl.uniprot.org/core/author | "Tang S."xsd:string |
| http://purl.uniprot.org/citations/17159989 | http://purl.uniprot.org/core/author | "Tecott L.H."xsd:string |
| http://purl.uniprot.org/citations/17159989 | http://purl.uniprot.org/core/author | "Huang E.J."xsd:string |
| http://purl.uniprot.org/citations/17159989 | http://purl.uniprot.org/core/author | "Pho V."xsd:string |
| http://purl.uniprot.org/citations/17159989 | http://purl.uniprot.org/core/author | "Holtzman J."xsd:string |
| http://purl.uniprot.org/citations/17159989 | http://purl.uniprot.org/core/author | "Hellmuth J."xsd:string |
| http://purl.uniprot.org/citations/17159989 | http://purl.uniprot.org/core/author | "Janak P.H."xsd:string |
| http://purl.uniprot.org/citations/17159989 | http://purl.uniprot.org/core/author | "Bonasera S.J."xsd:string |
| http://purl.uniprot.org/citations/17159989 | http://purl.uniprot.org/core/author | "Tang A.T."xsd:string |
| http://purl.uniprot.org/citations/17159989 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17159989 | http://purl.uniprot.org/core/name | "Nat Neurosci"xsd:string |
| http://purl.uniprot.org/citations/17159989 | http://purl.uniprot.org/core/pages | "77-86"xsd:string |
| http://purl.uniprot.org/citations/17159989 | http://purl.uniprot.org/core/title | "Essential function of HIPK2 in TGFbeta-dependent survival of midbrain dopamine neurons."xsd:string |
| http://purl.uniprot.org/citations/17159989 | http://purl.uniprot.org/core/volume | "10"xsd:string |
| http://purl.uniprot.org/citations/17159989 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/17159989 |
| http://purl.uniprot.org/citations/17159989 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/17159989 |
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| http://purl.uniprot.org/uniprot/P17125#attribution-B9F57744F303EA4100D6CC58BBD01243 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/17159989 |
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| http://purl.uniprot.org/uniprot/#_E9Q9G5-mappedCitation-17159989 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17159989 |