| http://purl.uniprot.org/citations/17174896 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17174896 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17174896 | http://www.w3.org/2000/01/rdf-schema#comment | "The RNA exosome is a multisubunit 3' to 5' exoribonuclease complex that participates in degradation and processing of cellular RNA. To determine the activities and structure of the eukaryotic exosome, we report the reconstitution of 9-subunit exosomes from yeast and human and reconstitution of 10- and 11-subunit exosomes from yeast. Comparative biochemical analysis between purified subunits and reconstituted exosomes using AU-rich, polyadenylated (poly[A]), generic, and structured RNA substrates reveals processive phosphorolytic activities for human Rrp41/Rrp45 and the 9-subunit human exosome, processive hydrolytic activities for yeast Rrp44 and the yeast 10-subunit exosome, distributive hydrolytic activities for Rrp6, and processive and distributive hydrolytic activities for the yeast 11-subunit exosome. To elucidate the architecture of a eukaryotic exosome, its conserved surfaces, and the structural basis for RNA decay, we report the X-ray structure determination for the 286 kDa nine-subunit human exosome at 3.35 A."xsd:string |
| http://purl.uniprot.org/citations/17174896 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.cell.2006.10.037"xsd:string |
| http://purl.uniprot.org/citations/17174896 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.cell.2006.10.037"xsd:string |
| http://purl.uniprot.org/citations/17174896 | http://purl.uniprot.org/core/author | "Liu Q."xsd:string |
| http://purl.uniprot.org/citations/17174896 | http://purl.uniprot.org/core/author | "Liu Q."xsd:string |
| http://purl.uniprot.org/citations/17174896 | http://purl.uniprot.org/core/author | "Lima C.D."xsd:string |
| http://purl.uniprot.org/citations/17174896 | http://purl.uniprot.org/core/author | "Lima C.D."xsd:string |
| http://purl.uniprot.org/citations/17174896 | http://purl.uniprot.org/core/author | "Greimann J.C."xsd:string |
| http://purl.uniprot.org/citations/17174896 | http://purl.uniprot.org/core/author | "Greimann J.C."xsd:string |
| http://purl.uniprot.org/citations/17174896 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/17174896 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/17174896 | http://purl.uniprot.org/core/name | "Cell"xsd:string |
| http://purl.uniprot.org/citations/17174896 | http://purl.uniprot.org/core/name | "Cell"xsd:string |
| http://purl.uniprot.org/citations/17174896 | http://purl.uniprot.org/core/pages | "1223-1237"xsd:string |
| http://purl.uniprot.org/citations/17174896 | http://purl.uniprot.org/core/pages | "1223-1237"xsd:string |
| http://purl.uniprot.org/citations/17174896 | http://purl.uniprot.org/core/title | "Reconstitution, activities, and structure of the eukaryotic RNA exosome."xsd:string |
| http://purl.uniprot.org/citations/17174896 | http://purl.uniprot.org/core/title | "Reconstitution, activities, and structure of the eukaryotic RNA exosome."xsd:string |
| http://purl.uniprot.org/citations/17174896 | http://purl.uniprot.org/core/volume | "127"xsd:string |
| http://purl.uniprot.org/citations/17174896 | http://purl.uniprot.org/core/volume | "127"xsd:string |
| http://purl.uniprot.org/citations/17174896 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/17174896 |
| http://purl.uniprot.org/citations/17174896 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/17174896 |
| http://purl.uniprot.org/citations/17174896 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/17174896 |
| http://purl.uniprot.org/citations/17174896 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/17174896 |