| http://purl.uniprot.org/citations/17187069 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17187069 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17187069 | http://www.w3.org/2000/01/rdf-schema#comment | "The caspase-recruitment domain-containing adaptor protein CARD9 regulates the innate signaling responses to fungal infection. Here we show that CARD9 is required for innate immune responses against intracellular pathogens. We generated Card9(-/-) mice and found that CARD9-deficient macrophages had defects in activation of the kinases p38 and Jnk but not of transcription factor NF-kappaB after bacterial and viral infection. CARD9-deficient mice failed to clear infection and showed altered cytokine production after challenge with Listeria monocytogenes. In wild-type cells, we found CARD9 inducibly associated with both the intracellular 'biosensor' Nod2 and the serine-threonine kinase RICK. Our data demonstrate that CARD9 has a critical function in Nod2-mediated activation of p38 and Jnk in innate immune responses to intracellular pathogens."xsd:string |
| http://purl.uniprot.org/citations/17187069 | http://purl.org/dc/terms/identifier | "doi:10.1038/ni1426"xsd:string |
| http://purl.uniprot.org/citations/17187069 | http://purl.org/dc/terms/identifier | "doi:10.1038/ni1426"xsd:string |
| http://purl.uniprot.org/citations/17187069 | http://purl.uniprot.org/core/author | "Li H."xsd:string |
| http://purl.uniprot.org/citations/17187069 | http://purl.uniprot.org/core/author | "Li H."xsd:string |
| http://purl.uniprot.org/citations/17187069 | http://purl.uniprot.org/core/author | "Lin X."xsd:string |
| http://purl.uniprot.org/citations/17187069 | http://purl.uniprot.org/core/author | "Lin X."xsd:string |
| http://purl.uniprot.org/citations/17187069 | http://purl.uniprot.org/core/author | "Wang D."xsd:string |
| http://purl.uniprot.org/citations/17187069 | http://purl.uniprot.org/core/author | "Wang D."xsd:string |
| http://purl.uniprot.org/citations/17187069 | http://purl.uniprot.org/core/author | "Zhang Y."xsd:string |
| http://purl.uniprot.org/citations/17187069 | http://purl.uniprot.org/core/author | "Zhang Y."xsd:string |
| http://purl.uniprot.org/citations/17187069 | http://purl.uniprot.org/core/author | "You Y."xsd:string |
| http://purl.uniprot.org/citations/17187069 | http://purl.uniprot.org/core/author | "You Y."xsd:string |
| http://purl.uniprot.org/citations/17187069 | http://purl.uniprot.org/core/author | "Dong C."xsd:string |
| http://purl.uniprot.org/citations/17187069 | http://purl.uniprot.org/core/author | "Dong C."xsd:string |
| http://purl.uniprot.org/citations/17187069 | http://purl.uniprot.org/core/author | "Duramad O."xsd:string |
| http://purl.uniprot.org/citations/17187069 | http://purl.uniprot.org/core/author | "Duramad O."xsd:string |
| http://purl.uniprot.org/citations/17187069 | http://purl.uniprot.org/core/author | "Hsu Y.M."xsd:string |
| http://purl.uniprot.org/citations/17187069 | http://purl.uniprot.org/core/author | "Hsu Y.M."xsd:string |
| http://purl.uniprot.org/citations/17187069 | http://purl.uniprot.org/core/author | "Qin X.F."xsd:string |
| http://purl.uniprot.org/citations/17187069 | http://purl.uniprot.org/core/author | "Qin X.F."xsd:string |
| http://purl.uniprot.org/citations/17187069 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17187069 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |