| http://purl.uniprot.org/citations/17202865 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17202865 | http://www.w3.org/2000/01/rdf-schema#comment | "The bone morphogenetic protein (BMP) family has been implicated in control of cartilage development. Here, we demonstrate that BMP-2 promotes chondrogenesis by activating p38 mitogen-activated protein kinase (MAPK), which in turn downregulates Wnt-7a/b-catenin signaling responsible for proteasomal degradation of Sox9. Exposure of mesenchymal cells to BMP-2 resulted in upregulation of Sox9 protein and a concomitant decrease in the level of b-catenin protein and Wnt-7a signaling. In agreement with this, the interaction of Sox9 with b-catenin was inhibited in the presence of BMP-2. Inhibition of the p38 MAPK pathway using a dominant negative mutant led to sustained Wnt-7a signaling and decreased Sox9 expression, with consequent inhibition of precartilage condensation and chondrogenic differentiation. Moreover, overexpression of b-catenin caused degradation of Sox9 via the ubiquitin/26S proteasome pathway. Our results collectively indicate that the increase in Sox9 protein resulting from downregulation of b-catenin/Wnt-7a signaling is mediated by p38 MAPK during BMP-2 induced chondrogenesis in chick wing bud mesenchymal cells."xsd:string |
| http://purl.uniprot.org/citations/17202865 | http://purl.org/dc/terms/identifier | "doi:10.1016/s1016-8478(23)17431-0"xsd:string |
| http://purl.uniprot.org/citations/17202865 | http://purl.uniprot.org/core/author | "Lee S.Y."xsd:string |
| http://purl.uniprot.org/citations/17202865 | http://purl.uniprot.org/core/author | "Kang S.S."xsd:string |
| http://purl.uniprot.org/citations/17202865 | http://purl.uniprot.org/core/author | "Bang O.S."xsd:string |
| http://purl.uniprot.org/citations/17202865 | http://purl.uniprot.org/core/author | "Jin E.J."xsd:string |
| http://purl.uniprot.org/citations/17202865 | http://purl.uniprot.org/core/author | "Choi Y.A."xsd:string |
| http://purl.uniprot.org/citations/17202865 | http://purl.uniprot.org/core/author | "Jung J.C."xsd:string |
| http://purl.uniprot.org/citations/17202865 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/17202865 | http://purl.uniprot.org/core/name | "Mol Cells"xsd:string |
| http://purl.uniprot.org/citations/17202865 | http://purl.uniprot.org/core/pages | "353-359"xsd:string |
| http://purl.uniprot.org/citations/17202865 | http://purl.uniprot.org/core/title | "BMP-2-enhanced chondrogenesis involves p38 MAPK-mediated down-regulation of Wnt-7a pathway."xsd:string |
| http://purl.uniprot.org/citations/17202865 | http://purl.uniprot.org/core/volume | "22"xsd:string |
| http://purl.uniprot.org/citations/17202865 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/17202865 |
| http://purl.uniprot.org/citations/17202865 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/17202865 |
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