| http://purl.uniprot.org/citations/17237785 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17237785 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17237785 | http://www.w3.org/2000/01/rdf-schema#comment | "Cytotoxic T lymphocytes and natural killer cells exert their cytotoxic activity through the polarized secretion of cytotoxic granules at the immunological synapse. Rab27a and hMunc13-4 are critical effectors of the exocytosis of cytotoxic granules. Here we show that the cytotoxic function of lymphocytes requires the cooperation of two types of organelles: the lysosomal cytotoxic granule and the endosomal 'exocytic vesicle'. Independently of Rab27a, hMunc13-4 mediated the assembly of Rab11(+) recycling and Rab27(+) late endosomal vesicles, constituting a pool of vesicles destined for regulated exocytosis. It also primed cytotoxic granule fusion, possibly through interaction with active Rab27a. Cytotoxic T lymphocyte-target cell recognition induced rapid polarization of both types of organelles, which coalesced near the cell-cell contact area. Our data provide insight into the regulation of the generation and release of cytotoxic granules by effector cytotoxic T lymphocytes and natural killer cells."xsd:string |
| http://purl.uniprot.org/citations/17237785 | http://purl.org/dc/terms/identifier | "doi:10.1038/ni1431"xsd:string |
| http://purl.uniprot.org/citations/17237785 | http://purl.org/dc/terms/identifier | "doi:10.1038/ni1431"xsd:string |
| http://purl.uniprot.org/citations/17237785 | http://purl.uniprot.org/core/author | "Fischer A."xsd:string |
| http://purl.uniprot.org/citations/17237785 | http://purl.uniprot.org/core/author | "Fischer A."xsd:string |
| http://purl.uniprot.org/citations/17237785 | http://purl.uniprot.org/core/author | "Raposo G."xsd:string |
| http://purl.uniprot.org/citations/17237785 | http://purl.uniprot.org/core/author | "Raposo G."xsd:string |
| http://purl.uniprot.org/citations/17237785 | http://purl.uniprot.org/core/author | "de Saint Basile G."xsd:string |
| http://purl.uniprot.org/citations/17237785 | http://purl.uniprot.org/core/author | "de Saint Basile G."xsd:string |
| http://purl.uniprot.org/citations/17237785 | http://purl.uniprot.org/core/author | "Knapnougel P."xsd:string |
| http://purl.uniprot.org/citations/17237785 | http://purl.uniprot.org/core/author | "Knapnougel P."xsd:string |
| http://purl.uniprot.org/citations/17237785 | http://purl.uniprot.org/core/author | "Romao M."xsd:string |
| http://purl.uniprot.org/citations/17237785 | http://purl.uniprot.org/core/author | "Romao M."xsd:string |
| http://purl.uniprot.org/citations/17237785 | http://purl.uniprot.org/core/author | "Feldmann J."xsd:string |
| http://purl.uniprot.org/citations/17237785 | http://purl.uniprot.org/core/author | "Feldmann J."xsd:string |
| http://purl.uniprot.org/citations/17237785 | http://purl.uniprot.org/core/author | "Ho C.-H."xsd:string |
| http://purl.uniprot.org/citations/17237785 | http://purl.uniprot.org/core/author | "Ho C.-H."xsd:string |
| http://purl.uniprot.org/citations/17237785 | http://purl.uniprot.org/core/author | "Menager M.M."xsd:string |
| http://purl.uniprot.org/citations/17237785 | http://purl.uniprot.org/core/author | "Menager M.M."xsd:string |
| http://purl.uniprot.org/citations/17237785 | http://purl.uniprot.org/core/author | "Menasche G."xsd:string |
| http://purl.uniprot.org/citations/17237785 | http://purl.uniprot.org/core/author | "Menasche G."xsd:string |
| http://purl.uniprot.org/citations/17237785 | http://purl.uniprot.org/core/author | "Garfa M."xsd:string |
| http://purl.uniprot.org/citations/17237785 | http://purl.uniprot.org/core/author | "Garfa M."xsd:string |